지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 79 - 84 (6page)
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초록· 키워드
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In an effort to discover an alternative antibiotic for treating infections with methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas sp. UJ-6, a marine bacterium that exhibited antibacterial activity against MRSA, was isolated. The culture broth and its ethyl acetate extract exhibited bactericidal activity against MRSA. The extract also exhibited antibacterial activity against gram-negative bacteria, which were not susceptible to vancomycin. The treatment of MRSA with the extract resulted in abnormal cell lysis. The extract retained >95% of its anti-MRSA activity after heat treatment for 15 min at 121°C. Thus, although most antibiotics are unstable under conditions of thermal stress, Pseudomonas sp. UJ-6 produces a heat-stable anti-MRSA substance. The results of this study strongly suggest that Pseudomonas sp. UJ-6 can be used to develop a novel, heat-stable, broad-spectrum antibiotic for the treatment of MRSA infections.
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참고문헌 (22)
참고문헌 신청
Abad MJ / 2011 / Marine compounds and their antimicrobial activities, In Science against Microbial Pathogens: Communicating Current Research and Technological Advances / Formatex Researc
Acebal C / 1998 / Two marine Agrobacterium producers of sesbanimide antibiotics / J Antibiot 51 : 64 ~ 67
Acebal C / 1999 / Agrochelin, a new cytotoxic antibiotic from a marine Agrobacterium: taxonomy, fermentation, isolation, physicochemical properties and biological activity /
Barna JCJ / 1984 / The structure and mode of action of glycopeptide antibiotics of the vancomycin group / Annu Rev Microbiol 38 : 339 ~ 357
Barsby T / 2001 / Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics / Org Lett 3 : 437 ~ 440
Acebal C / 1998 / Two marine Agrobacterium producers of sesbanimide antibiotics / J Antibiot 51 : 64 ~ 67
Acebal C / 1999 / Agrochelin, a new cytotoxic antibiotic from a marine Agrobacterium: taxonomy, fermentation, isolation, physicochemical properties and biological activity /
Barna JCJ / 1984 / The structure and mode of action of glycopeptide antibiotics of the vancomycin group / Annu Rev Microbiol 38 : 339 ~ 357
Barsby T / 2001 / Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics / Org Lett 3 : 437 ~ 440
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