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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 267 - 274 (8page)
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Bacterial lipopolysaccharide (LPS) induces expression of pro-inflammatory cytokines and enzymes producing nitric oxide (NO) and prostaglandins (PGs) in immune cells. This process is mediated by the activation of nuclear factor kappaB (NF-κB). In this study, we investigated the anti-inflammatory characteristics of Codium fragile ethanolic extract (CFE) mediated by the regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) using LPS-stimulated murine macrophage RAW 264.7 cells. CFE significantly inhibited LPS-induced NO and PGE2 production in a dose-dependent manner and suppressed the expression of iNOS and COX-2 proteins in LPS-stimulated RAW 264.7 cells with no cytotoxicity. Pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, were significantly reduced by treatment of CFE in LPS-stimulated RAW 264.7 cells. CFE inhibited the promoter activity of (NF)-κB in LPS-stimulated macrophages. Treatment with CFE suppressed translocation of the NF-κB p65 subunit by preventing proteolytic degradation of inhibitor of κB-α. These results indicate that the CFE-mediated inhibition of NO and PGE_2 production in LPS-stimulated RAW 264.7 cells is mediated through the NF-κB-dependent transcriptional downregulation of iNOS and COX-2, suggesting the potential of CFE as a nutraceutical with anti-inflammatory activity.
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참고문헌 (25)
참고문헌 신청
Abad MJ / 2008 / Natural marine anti-inflammatory products / Mini Rev Med Chem 8 : 740 ~ 754
Beutler B / 1989 / The biology of cachectin/TNF--a primary mediator of the host response / Annu Rev Immunol 7 : 625 ~ 655
Blunt JW / 2010 / Marine natural products / Nat Prod Rep 27 : 165 ~ 237
Chen Z / 1995 / Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway / Genes Dev 9 : 1586 ~ 1597
Chung EY / 2011 / Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation / J Nutr Biochem 2
Beutler B / 1989 / The biology of cachectin/TNF--a primary mediator of the host response / Annu Rev Immunol 7 : 625 ~ 655
Blunt JW / 2010 / Marine natural products / Nat Prod Rep 27 : 165 ~ 237
Chen Z / 1995 / Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway / Genes Dev 9 : 1586 ~ 1597
Chung EY / 2011 / Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation / J Nutr Biochem 2
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