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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 35 - 44 (10page)
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We previously identified Streptomyces griseus as an anti-cancer agent (Kim et al., 2014). In this study, we isolated compounds from S. griseus and evaluated their anticancer effect and toxicity in vitro and in vivo. Preparative centrifugal partition chromatography (CPC) was used to obtain three compounds, cyclo(L-[4-hydroxyprolinyl]- L –leucine], cyclo(L-Phe-trans-4-hydroxy-L-Pro) and phenethyl acetate (PA). We chose PA, which had the highest anticancer activity, as a target compound for further experiments. PA induced the formation of apoptotic bodies, DNA fragmentation, DNA accumulation in G0/G1 phase, and reactive oxygen species (ROS) formation. Furthermore, PA treatment increased Bax/Bcl-xL expression, activated caspase-3, and cleaved poly-ADP-ribose polymerase (PARP) in HL-60 cells. Simultaneous evaluation in vitro and in vivo, revealed that PA exhibited no toxicity in Vero cells and zebrafish embryos. We revealed, for the first time, that PA generates ROS, and that this ROS accumulation induced the Bcl signaling pathway.
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참고문헌 (23)
참고문헌 신청
Arctander S / / Perfume and Flavor Chemicals (Aroma Chemicals), 2
Bewley CA / 1998 / Lithistid sponges: Star performers or hosts to the stars? / Angewandte Chemie International Edition : 2162 ~ 2178
Bringmann G / 2003 / Evariquinone, isoemericellin, and stromemycin from a sponge derived strain of the fungus Emericella variecolor / Phytochemistry 63 : 437 ~ 443
Bringmann G / 2005 / The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain / Tetrahedron 61 : 72
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat. Rev. Cancer 2 : 647 ~ 656
Bewley CA / 1998 / Lithistid sponges: Star performers or hosts to the stars? / Angewandte Chemie International Edition : 2162 ~ 2178
Bringmann G / 2003 / Evariquinone, isoemericellin, and stromemycin from a sponge derived strain of the fungus Emericella variecolor / Phytochemistry 63 : 437 ~ 443
Bringmann G / 2005 / The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain / Tetrahedron 61 : 72
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat. Rev. Cancer 2 : 647 ~ 656
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