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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 341 - 347 (7page)
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초록· 키워드
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Sea anemone (phylum Cnidarian) has been recognized as a new source of marine bioactive compounds due to the growth of marine bioprospecting. Studies of bioactive compounds in cnidarians have focused mainly on antitumor compounds, such as toxins in aqueous extracts and terpenoids in organic solvent extracts. In this study, we evaluated the biological activities of five water extracts of tissue of the mottled anemone Urticina crassicornis. Most extracts exhibited broad-spectrum antimicrobial activity as determined by ultrasensitive radial diffusion assay (URDA) against gram-positive and -negative bacteria, including a fish pathogen, Aeromonas hydrophila, but no activity against fungi. The activity of the extracts was abolished by tryptic digestion, indicating that protein compounds were responsible for the antimicrobial activity. Furthermore, in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging activity assay, only the visceral tissue extract showed activity. However, no extract had hemolytic activity against human red blood cells. Consequently, this study suggests the water-soluble extract of mottled anemone to be a promising source of proteinaceous antimicrobial compounds that can be utilized for development of novel antibiotics.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alhazmi MI / 2015 / Isolation of Aeromonas spp. from Food Products : Emerging Aeromonas Infections and Their Significance in Public Health / J AOAC Int 98 : 927 ~ 929
Alma MH / 2003 / Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey / Biol
Aneiros A. / 2004 / Bioactive peptides from marine sources : pharmacological properties and isolation procedures / J Chromatogr B Analyt Technol Biomed Life Sci 803 : 41 ~ 53
Bhakuni DS / 2006 / Bioactive marine natural products / Springer Science & Business Media
Bradshaw J / 2003 / Cationic antimicrobial peptides : issues for potential clinical use / BioDrugs 17 : 233 ~ 240
Alma MH / 2003 / Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey / Biol
Aneiros A. / 2004 / Bioactive peptides from marine sources : pharmacological properties and isolation procedures / J Chromatogr B Analyt Technol Biomed Life Sci 803 : 41 ~ 53
Bhakuni DS / 2006 / Bioactive marine natural products / Springer Science & Business Media
Bradshaw J / 2003 / Cationic antimicrobial peptides : issues for potential clinical use / BioDrugs 17 : 233 ~ 240
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