지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 58 - 63 (6page)
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초록· 키워드
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Background: To compare the effects of low dose and high dose of statin treatment on endothelial function and carotid intimamedia thickness (IMT) in patients with variant angina (VAP).
Methods: A total of 70 patients with VAP were divided into two groups; atorvastatin 10 mg treatment group (group I: n = 35,54.2 ± 12.5 years) versus atorvastatin 40 mg treatment group (group II: n = 35, 52.6 ± 9.8 years). Flow mediated vasodilation (FMD) of the brachial artery and IMT of the carotid artery were compared between the groups after 6 months of statin treatment.
Results: The baseline FMD and carotid IMT were not different between the groups. After 6 months of statin therapy, FMD was significantly improved in both groups (7.7 ± 2.5% to 8.9 ± 2.2% in group I, p = 0.001, 7.9 ± 2.7% to 9.5 ± 2.8% in group II, p < 0.001), but the degree of FMD change and FMD at 6 month were not different between the groups. Carotid IMT were not changed in both groups after 6 months of statin therapy.
Conclusion: The use of statin for 6 months significantly improved endothelial function in patients with VAP, but carotid IMT was not changed. The use of high dose statin did not show significant additional benefit as compared with the use of low dose statin. The present study suggested that statin therapy would be beneficial in the treatment of VAP.
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참고문헌 (30)
참고문헌 신청
김계훈 / 2009 / Clinical Effects of Calcium Channel Blocker and Angiotensin Converting Enzyme Inhibitor on Endothelial Function and Arterial Stiffness in Patients with Angina Pectoris / Journal of Korean Medical Science 24(2):223~231
이영수 / 2008 / The Short-term Effect of Atorvastatin on Flow-Mediated Vasodilation, Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients With Moderate Cholesterolemia / Korean Circulation Journal 38(3):144~151
Reriani MK / 2011 / Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-analysis of randomized controlled trials / Eur J Cardiovasc Prev Rehabil 18:704~716
Liu B / 2012 / Effect of rosuvastatin on ROCK activity, endothelial function, and inflammation in Asian patients with atherosclerosis / Intern Med 51:1177~1182
Zhang L / 2012 / Meta-analysis of the effects of statin therapy on endothelial function in patients with diabetes mellitus / Atherosclerosis 223:78~85
이영수 / 2008 / The Short-term Effect of Atorvastatin on Flow-Mediated Vasodilation, Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients With Moderate Cholesterolemia / Korean Circulation Journal 38(3):144~151
Reriani MK / 2011 / Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-analysis of randomized controlled trials / Eur J Cardiovasc Prev Rehabil 18:704~716
Liu B / 2012 / Effect of rosuvastatin on ROCK activity, endothelial function, and inflammation in Asian patients with atherosclerosis / Intern Med 51:1177~1182
Zhang L / 2012 / Meta-analysis of the effects of statin therapy on endothelial function in patients with diabetes mellitus / Atherosclerosis 223:78~85
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