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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 201 - 207 (7page)
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초록· 키워드
오류제보하기
Background: Left ventricle (LV) in patients with aortic stenosis (AS) faces a double hemodynamic load incorporating both valvularstenosis and reduced systemic arterial compliance (SAC). This study aimed to evaluate the impact of global LV afterload onLV hypertrophy (LVH) before and after aortic valve replacement (AVR).
Methods: The study cohort included 453 patients (247 males; mean age, 64 ± 11 years) who underwent AVR. Pre- and post-AVR echocardiographic examinations were retrospectively analyzed including an index of valvuloarterial impedance (ZVA) and LVmass index/LV end-diastolic volume index (LVMI/LVEDVI) as a parameter of LVH.
Results: Pre-AVR LVMI/LVEDVI was 2.7 ± 0.9 g/mL with an aortic valve area (AVA) of 0.6 ± 0.2 cm2. ZVA was 5.9 ± 1.9mm Hg/mL/m2 and showed a stronger correlation (β = 0.601, p < 0.001) with pre-AVR LVMI/LVEDVI than indexed AVA (β =0.061, p = 0.19), transvalvular peak velocity (β = 0.211, p < 0.001). During a median follow-up of 3.5 years, patients had a 18.8± 10.4% decrease in the LV geometry index with a decrease in SAC from 1.20 ± 0.48 to 1.00 ± 0.38 mL/m2/mm Hg (p < 0.001).
Pre-AVR LV ejection fraction (r = 0.284, p < 0.001) and ZVA (r = 0.523, p < 0.001) were independent factors associated with LVHregression in 322 patients with follow-up duration >1 year after AVR.
Conclusion: ZVA is a major determinant of concentric remodeling in AS before AVR and LVH regression after AVR, whichshould be incorporated in routine evaluation of AS.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Briand M / 2005 / Reduced systemic arterial compliance impacts significantly on left ventricular afterload and function in aortic stenosis: implications for diagnosis and treatment / J Am Coll Cardiol 46:291~298
Hachicha Z / 2007 / Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival / Circulation 115:2856~2864
Hachicha Z / 2009 / Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis / J Am Coll Cardiol 54:1003~1011
Cramariuc D / 2009 / Low-flow aortic stenosis in asymptomatic patients:valvular-arterial impedance and systolic function from the SEAS Substudy / JACC Cardiovasc Imaging 2:390~399
Weisz SH / 2014 / Carotid artery and aortic stiffness evaluation in aortic stenosis / J Am Soc Echocardiogr 27:385~392
Hachicha Z / 2007 / Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival / Circulation 115:2856~2864
Hachicha Z / 2009 / Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis / J Am Coll Cardiol 54:1003~1011
Cramariuc D / 2009 / Low-flow aortic stenosis in asymptomatic patients:valvular-arterial impedance and systolic function from the SEAS Substudy / JACC Cardiovasc Imaging 2:390~399
Weisz SH / 2014 / Carotid artery and aortic stiffness evaluation in aortic stenosis / J Am Soc Echocardiogr 27:385~392
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