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Background and Objectives:For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. ment modality with chemotherapy is applied, although resistance to chemotherapy makes chemotherapy les effective. The Cisplatin-based chemotherapy has been widely used in the field of nasopharyngeal cancer. The Cisplatin resistance is known to be caused by the multidrug resistance-asociated protein (MRP), which is one of the drug-export pumps and the glutathione S-transferase (GST)-pi which catalyzes the conjugation of the GSH (glutathione) and the cisplatin. The aim of this study is Subjects and Method:We analyzed tumor tissues from 49 cases of parafin block specimens which were diagnosed with NPC and treated at Chonnam National University Hospital. The imunohistochemical study for the GST-pi and the MRP was perfor-med with parafin block specimens of nasopharyngeal cancers. Results:In the GST-pi, the relationship betwen the early stage (64.3%) and the advanced stage (91.4%) was statistically significant (p=0.020). The expresion of the GST-pi and the MRP had no relationship with the clinical factor, the response to chemotherpy and the survival rate. Conclusion:Because the expresion of the GST-pi and the MRP in the nasopharyngeal carcinoma could not predict the response to chemotherapy. So the efforts to find the predictive value of the chemotherapy are needed. (Korean J Otolaryngol 2002;45:791-5)

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