인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 462 - 466 (5page)
이용수
초록· 키워드
Background and Objectives:The clasic imunotherapy has the inconvenience and the risk of anaphylaxis. Recent reports revealed that imunostimulatory DNA sequences (CpG motif, ISS-ODN) have been shown to act as strong Th1 response-inducing adjuvants and DNA based vaccination might be an effective therapeutic option for the treatment of allergic disease. In our study, we investigated whether ISS-ODN have anti-allergic efect in the mouse rhinitis model of Dermatophagoides farinae (Der f), the most common allergen in Korea. Materials and Method:C57BL/6 mice were sensitized with crude extract of Der f extract. After injection of ISS-ODN, several parameters of allergic response were evaluated. Results:In-jection with ISS-ODN supressed itching symptom, eosinophilic infiltration into nasal mucosa and the splenic T cell pr-oliferation after Der f allergen challenge in the murine model of allergic rhinitis. However, injection with ISS-ODN did not show a detectable Der f-specific IgE suppresion. Conclusion:in the allergic rhinitis model of Der f allergen. House dust mite allergy can be reduced by the injection with ISS-ODN. (Korean J Otolaryngol 2002;45:462-6)
#Dermatophagoides farinae ·알레르기 비염·동물모델·CpG motif·면역강화 s equence.
#Dermatophagoides farinae· Allergic rhinitis· Murine model· CpG motif· Imunostimulatory sequence.
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