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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제4호
발행연도
2007.1
수록면
310 - 313 (4page)

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Background and Objectives: the nasal cavity and occur on both infectious and noninfectious basis, and genetic etiology is suspected in the development of nasal polyps. 5-Lipoxygenase is the first enzyme committed in the metabolic pathway leading to the intracellular synthesis of leukotrienes. Some studies have shown that leuko-trienes were significantly higher in nasal polyps from aspirin-sensitive asthmatics than in nasal polyps from aspirin-tolerant asthmatics and normal nasal mucosa. The purpose of the present study is to evaluate whether genetic polymorphism of the core promoter region of the 5-lipoxygenase gene contributes to the development of nasal polyps. Subjects and Method:This study was conducted in 97 nasal polyp patients associated with chronic sinusitis and 92 healthy controls. Genetic polymorphisms of 5-lipoxygenase gene promoter were genot Results:There were no significant differences between the 5-lipoxygenase gene promoter polymorphisms in nasal polyp patients with chronic sinusitis and those in healthy controls (p= 0.76). In the nasal polyp patients associated with chronic sinusitis, the frequencies of 6-bp deletion were lower than those of healthy controls (OR, 0.88 95% CI, 0.48- 1.60), but there was no statistical significance (p= 0.67). The frequencies of 6-bp addition were higher than those of healthy controls (OR, 1.96; 95% CI, 0.33- 10.6), but no significant diference was found (p= 0.68). Conclusion:We concluded that 5-lipoxygenase gene promoter polymorphism did not show genetic predisposition with regard to nasal polyps in the Korean population. (Korean J Otolaryngol 2007 ;50 :310-3)

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