폐쇄성수면무호흡증이 심혈관 교감신경에 미치는 영향에 대한 연구

정주현; 김선영; 윤병기; 강일규; 김선태; 박기형

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자료유형: 학술저널

저자정보: 정주현 김선영 윤병기 강일규 김선태 박기형

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제11호

발행연도: 2008.1

수록면: 1,020 - 1,024 (5page)

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The previous studies have shown that patients with obstructive sleep apnea (OSA) have shown high levels of cardiovascular diseases. These cardiovascular diseases are related to imbalance of cardiac autonomic systems. Alteration of QT interval in EKG reflects the increased cardiac sympathetic activity. The purpose of this study is to compare the cardiac sympathetic nerve activity between the control and OSA patients. Subjects and Method：All the patients were divided into the control group (n=20), whose RDI was less than 5 and the OSA group (n=40), whose RDI was more than 5. The OSA group was also divided into 3 groups, mild, moderate and severe, according to their RDI. The corrected QT interval (QTc) in EKG was checked at day time and during polysomnography. Results：The number of hypertensive patients was significantly greater in the OSA group than the control group (p<0.001). The QTc interval was increased proportional to the RDI (p<0.001). There was a significant difference in the QTc intervals between the daytime period and apnea peak (p=0.031). Conclusion：Our results showed that the QT prolongation might be a prognostic factor in predicting the cardiac sympathetic hyperactivity in obstructive sleep apnea patients. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:1020-4)

#Obstructive sleep apnea·Respiratory distress index·QT interval.

참고문헌 (19)

참고문헌 신청

Aytemir K / 2007 / Increased myocardia vulnerability and autonomic nervous system imbalance in obsturtive sleep apnea syndrome / Respir Med 101 (6) : 1277 ~ 1282

Carlson J / 1991 / Augmented sympathetic activity in awake patients with obstructive sleep apnea / Sleep 20 : 297 ~

Chrysostomakis SI / 2006 / Continuous positive airway pressure therapy lowers vagal tone in patients with obstructive sleep apnoea-hypopnoea syndrome / Hellenic J Cardiol 47

Fletcher EC / 1987 / Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension / Sleep 10 (1) : 35 ~ 44

Goldberger / / Clinical Elextrocardiograohy: Asimplified Approach / Basic ECG Waves : 14 ~ 16

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