토끼의 후성문 창상모델에서 Mitomycin-C 도포를 통한후성문협착의 예방효과

노종렬; 윤여훈; 구본석; 나기상; 박찬일

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자료유형: 학술저널

저자정보: 노종렬 윤여훈 구본석 나기상 박찬일

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제10호

발행연도: 2005.1

수록면: 1,261 - 1,266 (6page)

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연구방법

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연구결과

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Background and Objectives：Posterior glottic stenosis (PGS) is a disabling disease and most commonly induced by trauma from endotracheal intubation. We performed a randomized, controlled study with three animal groups to investigate the preventive effect of mitomycin-C on the posterior glottis undergone laser injury. Materials and Method：Twenty rabbits were available for evaluation. Group 1 (n=7) and 2 (n=6) were treated with topical mitomycin-C of 0.4 and 1.0 mg/ml, respectively, with the group 3 (n=7) used as the control. All animals underwent laser injury of 6 W, continuous mode on the posterior glottis. Group 1 and 2 were treated by a single topical use of cottonoid soaked in mitomycin-C solution on the injured posterior glottis for 5 minutes and the group 3 by saline. The posterior glottis of all groups was evaluated by telescopic examinations under direct laryngoscopy 2 months after the injury and was harvested for histological staining with hematoxylin-eosin and Masson trichrome. Results：The scar, granulation tissue and synechia formation of the posterior glottis was clearly induced by laser injury. Microscopic examinations showed increased collagen content and fibroblast proliferation in the region. Topical use of mitomycin- C significantly decreased the incidence of such gross and microscopic changes of the posterior glottis (p<.05). Conclusion： Mitomycin-C prevents PGS via its anti-proliferative effect on fibroblasts. The use of Mitomycin-C is warranted for patients witha history of prolonged intubation or for those who have undergone surgery of the posterior glottis.

#후성문협착·후연합·후두·토끼·Mitomycin-C. #Posterior glottic stenosis·Posterior commissure·Larynx·Rabbit·Mitomycin-C.

참고문헌 (14)

참고문헌 신청

/ 1980 / Posterior glottic laryngeal stenosis 88 : 765 ~ 72

/ 1983 / Posterior commissure stenosis post long-term intubation 93 : 1314 ~ 8

/ 1988 / Laryngeal injury from prolonged endotracheal intubation 98 : 1 ~ 15

/ 1993 / Posterior glottic stenosis in children 28 : 11 ~ 23

/ 1993 / Prolonged localized tissue effects from 5-minute exposuresto fluorouracil and mitomycin C 111 : 263 ~ 7

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