지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 123 - 130 (8page)
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초록· 키워드
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Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes to pathophysiologic conditions such as rhinitis, asthma, and chronic obstructive pulmonary disease etc. The study on mucin hypersecretion has long been worked, but the exact molecular composition and mechanism for exocytic machinery remain mostly to be elucidated. The regulated mucin secretion, highly coordinated process, is mediated by the cooperative interaction of several proteins existing in the secretory granule, cytoplasm, and plasma membrane. This review provides the information on molecular components of the core exocytic machinery and their functional roles for mucin exocytosis in airway secretory cells.
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참고문헌 (41)
참고문헌 신청
Hay JC / 1997 / SNAREs and NSF in targeted membrane fusion / Curr Opin Cell Biol 9(4):505~512
Bock JB / 1997 / Protein transport. A fusion of new ideas / Nature 387(6629):133~135
Hanson PI / 1997 / Neurotransmitter release-four years of SNARE complexes / Curr Opin Neurobiol 7(3):310~315
Behrendorff N / 2011 / Vesicleassociated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion / J Biol Chem 286(34):29627~29634
Jones LC / 2012 / VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells / J Physiol 590(Pt 3):545~562
Bock JB / 1997 / Protein transport. A fusion of new ideas / Nature 387(6629):133~135
Hanson PI / 1997 / Neurotransmitter release-four years of SNARE complexes / Curr Opin Neurobiol 7(3):310~315
Behrendorff N / 2011 / Vesicleassociated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion / J Biol Chem 286(34):29627~29634
Jones LC / 2012 / VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells / J Physiol 590(Pt 3):545~562
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