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Background and Objectives Drug-induced sedation endoscopy (DISE) has recently gainedpopularity among otolaryngologists because it can provide direct information of upper airwayobstruction in patients with obstructive sleep apnea (OSA). In that regard, we examined howDISE examination affected the decision of clinician’s treatment plan and the consequent patient’scompliance in OSA patients. Subjects and Method All enrolled patients were classified into two groups according to themethod of upper airway evaluation employed: a physical examination only group and a physicalexamination combined with DISE group. The clinician’s treatment plan was categorized intothe following four groups: sleep surgery, positive airway pressure, oral appliance, and sleep surgerycombined with oral appliance. The change of patient’s compliance was also evaluated. Results There were several differences in how DISE evaluation affected the decision of clinician’streatment plan and patient’s compliance between the two groups. The rate for sleep surgeryfell from 69.6% to 15.9%; on the other hand, the rate for positive airway pressure, oralapplianceand sleep surgery combined with oral appliance all increased from 13.0% to 36.2%,14.5% to 26.6%, and 2.9% to 21.3%, respectively. The patient’s compliance also changed afterDISE evaluation: sleep surgery, positive airway pressure, oral appliance and sleep surgery combinedwith oral appliance all increased from 78.1% to 87.9%, 16.7% to 76.0%, 25.0% to 87.3%,and 50.0% to 91.03%, respectively. Conclusion We found that DISE examination influences the decision of clinician’s treatmentplan and patient’s compliance. We suggest additional cohort studies to confirm these findings.

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