지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제4권 제2호
- 발행연도
- 2011.1
- 수록면
- 101 - 104 (4page)
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초록· 키워드
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Objectives. To evaluate the significance of laryngopharyngeal reflux (LPR) as a risk factor in laryngeal cancer.
Methods. We performed a case-control study with 29 consecutive laryngeal cancer patients who had undergone 24-hour ambulatory double pH monitoring from 2003 to 2006. The control group included 300 patients who had undergone 24-hour ambulatory double pH monitoring due to LPR-related symptoms. We analyzed the prevalence of LPR and numerous parameters from the 24-hour ambulatory double pH monitoring in the laryngeal cancer patient and control groups. Pathologic LPR is defined when more than three episodes of LPR occur in 24 hours.
Results. The prevalence of pathologic LPR was significantly higher in the laryngeal cancer group than the control group (P=0.049). The reflux number of the upper probe was significantly higher in the laryngeal cancer group (P<0.001). However the effects of pathologic LPR on laryngeal cancer risk were diluted after adjusting for smoking and alcohol consumption in the multivariable logistic regression.
Conclusion. The pathologic LPR might be a possible risk factor in the development of laryngeal cancer. A further study should be necessary to verify the exact role of LPR in laryngeal cancer.
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참고문헌 (19)
참고문헌 신청
Bacciu A / 2004 / Effects of gastroesophageal reflux disease in laryngeal carcinoma / Clin Otolaryngol Allied Sci 29 (5) : 545 ~ 548
Chung JH / 2009 / The significance of laryngopharyngeal reflux in benign vocal mucosal lesions / Otolaryngol Head Neck Surg 141 (3) : 369 ~ 373
Copper MP / 2000 / High incidence of laryngopharyngeal reflux in patients with head and neck cancer / Laryngoscope 110 (6) : 1007 ~ 1011
El-Serag HB / 2001 / Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer / Am J Gastroenterol 96 (7) : 2013 ~ 2018
Gabriel CE / 1960 / The importance of chronic laryngitis / J Laryngol Otol 74 : 349 ~ 357
Chung JH / 2009 / The significance of laryngopharyngeal reflux in benign vocal mucosal lesions / Otolaryngol Head Neck Surg 141 (3) : 369 ~ 373
Copper MP / 2000 / High incidence of laryngopharyngeal reflux in patients with head and neck cancer / Laryngoscope 110 (6) : 1007 ~ 1011
El-Serag HB / 2001 / Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer / Am J Gastroenterol 96 (7) : 2013 ~ 2018
Gabriel CE / 1960 / The importance of chronic laryngitis / J Laryngol Otol 74 : 349 ~ 357
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