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김영효; 장태영; 김재은; 임동욱; 김규성

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자료유형: 학술저널

저자정보: 김영효 장태영 김재은 임동욱 김규성

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제53권 제10호

발행연도: 2010.1

수록면: 615 - 619 (5page)

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연구주제

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연구배경

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연구방법

🏆

연구결과

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Background and Objectives Although different methods of collecting nasal fluid exist and can influence the result of the study, there have not been any studies made yet to compare the different methods. The authors aimed to evaluate the usefulness of these methods by comparing the albumin concentration of nasal fluid after nasal provocation in patients with allergic rhinitis. Subjects and Method In 22 patients with allergic rhinitis, we measured the change of nasal obstruction and rhinorrhea after nasal provocation using Visual Analogue Scale (VAS). In Group A (n=10), the nasal lavage and direct suction method were used and in Group B (n=12), nasal lavage and filter paper method were used. Nasal fluids were obtained before, 20 min after and 8 hours after provocation. The concentration of albumin was calculated using rate nephelometry. Results Patientsʼ nasal symptoms were aggravated in early allergic reaction but subsided in late reaction. There was meaningful increase of albumin concentration with the use of direct suction and filter paper methods. In contrast, there was no significant increase of concentration with the use of lavage method. Conclusion The filter paper method is superior in the quantitative analysis of mediators in nasal fluid after nasal provocation in allergic patients. The lavage method, however, is considered inappropriate because of its dilution effect. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:615-9

#Nasal lavage fluid ㆍNasal provocation tests ㆍAllergic rhinitis.

참고문헌 (15)

참고문헌 신청

Adkinson NF Jr / 2009 / Middleton’s allergy: principles and practice. 7th ed / Mosby : 1281 ~ 1282

Besancon-Watelet C / 2002 / Eosinophilia and cell activation mediators in nasal secretions / Laryngoscope 112 (1) : 43 ~ 46

Biewenga J / 1991 / Nasal secretions from patients with polyps and healthy individuals, collected with a new aspiration system: evaluation of total protein and immunoglobulin

Gevaert P / 2006 / Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps / J Allergy Clin Immunol 118 (5) : 1133 ~ 1141

Hilding AC / 1972 / Simple method for collecting near-normal human nasal secretion / Ann Otol Rhinol Laryngol 81 (3) : 422 ~ 423

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