인체면역결핍바이러스 감염 환자에서 발생한 이비인후과 질환의 분석

조규섭; 이덕규; 박영대; 신성찬; 이선희; 노환중

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자료유형: 학술저널

저자정보: 조규섭 이덕규 박영대 신성찬 이선희 노환중

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제6호

발행연도: 2009.1

수록면: 506 - 511 (6page)

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Background and Objectives：As human immunodeficiency virus (HIV) infection increases in prevalence and new medical therapies prolong the survival of HIV-infected patients, otolaryngologists will see a larger number of patients with head and neck manifestations of HIV infection. The aims of study were to evaluate the various otorhinolaryngologic diseases and to analyze the useful markers for predicting immune function in HIV-infected patients. Subjects and Method：Of 380 HIV-infected patients, 40 patients (10.5%；39 males and 1 female, age ranging from 23 to 55) were referred to otorhinolaryngologists. Spectrum of disease and correlation between various surrogate markers (HIV RNA, leukocyte count, neutrophil, lymphocyte, CD3, CD4, CD8 T cell percentage and count, CD4/CD8 ratio) and risk of infectious otorhinolaryngologic diseases were analyzed. Results： Thirty-three patients (82.5%) were infectious, 6 patients (15.0%) had non-infectious diseases and 1 patient (2.5%) malignancy. In otologic diseases, acute otitis media and chronic otitis media were frequently found in the mentioned order. In rhinologic diseases, rhinosinusitis and vestibulitis were frequently found in the mentioned order, with one primary extra nodal non-Hodgkin’s lymphoma. In laryngologic diseases, pharyngolaryngitis, oral candidiasis, stomatitis were frequently found. In the surrogate markers of immune function, CD4 percentage, CD4 count and CD4/CD8 ratio were found significantly lower in the infectious diseases than in the non-infectious disease. Conclusion：Of HIV-infected patients, 10.5% had seen an otolaryngologist, and the majority had infectious diseases. The risk of infectious diseases was strongly correlated with the CD4 percentage, count and CD4/CD8 ratio.

#인체면역결핍바이러스 감염·이비인후과·CD 4 림프구 #HIV infections·Otolaryngology·CD4 lymphocyte count

참고문헌 (20)

참고문헌 신청

/ 1992 / 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults / MMWR Recomm Rep (41) : 1 ~ 19

Baroni CD / 1993 / The lymphadenopathy of HIV infection / Am J Clin Pathol 99 (4) : 397 ~ 401

Barr CE / 1992 / Oral diseases in HIV-1 infection / Dysphagia 7 (3) : 126 ~ 137

Birchall MA / 1994 / Changing patterns of HIV infection in otolaryngology / Clin Otolaryngol Allied Sci 19 (6) : 473 ~ 477

Chaisson RE / 1987 / Tuberculosis in patients with the acquired immunodeficiency syndrome. Clinical features, response to therapy, and survival / Am Rev Respir Dis 136 (3) :

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