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Background and Objectives Deep neck infection may still be lethal especially when life-threatening complications occur. The objective of this study is to clarify the therapeutic module for deep neck infection and analyze epidemiologic characteristics, clinical course, microorganisms and site of infections. Subjects and Method We retrospectively reviewed the medical charts of 98 patients who were confirmed with deep neck infection and who received treatment at the Soonchunhyang University Hospital between 2000 and 2009. We analyzed the data for deep neck infection using the statistical tools like t-test and Spearman’s coefficient of correlation. Results The parapharyngeal space was the most commonly involved space in deep neck infection. The most common pathogen was Streptococcus. The most common underlying disease was Diabetes mellitus. Conclusion Statistical dada showed that there was no significant correlation between the hospitalization period and deep neck infection. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:627-31

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