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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제1호
- 발행연도
- 2010.1
- 수록면
- 13 - 17 (5page)
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초록· 키워드
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Objectives. In this study, we evaluated the efficacy of nebulized bovine pulmonary surfactant on experimentally induced otitis media with effusion (OME) in guinea pigs.
Methods. Twenty guinea pigs were divided into three groups. Four untreated animals served as normal controls. Experimental OME was established in both ears of the remaining 16 animals by a transbullar injection of 10 mL of Pseudomonas aeruginosa lipopolysaccharide in saline. Thereafter, the guinea pigs received nebulized phosphate buffered saline (n=8) or nebulized bovine pulmonary surfactant (n=8). Nebulization was given daily for 7 days. On day 8,all the animals’ passive opening pressure (POP) of the Eustachian tube was measured and histopathological observations of the bulla were made by light microscopy.
Results. Nebulized bovine pulmonary surfactant significantly reduced the POP compared to that of saline nebulization.
The bovine pulmonary surfactant improved the tubal patency and produced less histopathologcally-evident edematous bullar mucosa.
Conclusion. Nebulization of bovine pulmonary surfactant plays an important role in treating otitis media with effusion in guinea pigs. Our results suggest that the chosen nebulized bovine pulmonary surfactant can be of good clinical benefit for treating OME in the future.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Birken EA / 1972 / Surface tension lowering substance of the canine Eustachian tube / Ann Otol Rhinol Laryngol 81 (2) : 268 ~ 71
Bluestone CD / 1983 / Eustachian tube function:physiology,pathophysiology,and role of allergy in pathogenesis of otitis media / J Allergy Clin Immunol 72 (3) : 242 ~ 251
Chabot S / 2003 / Surfactant protein A inhibits lipopolysaccharide-induced in vivo production of interleukin-10 by mononuclear phagocytes during lung inflammation / Am J Res
Chandrasekhar SS / 2002 / Intranasal metered dose aerosolized surfactant reduces passive opening pressure of the eustachian tube:comparison study in two animal models / Otol
Chandrasekhar SS / 2004 / Otitis media:treatment with intranasal aerosolized surfactant / Laryngoscope 114 (3) : 472 ~ 485
Bluestone CD / 1983 / Eustachian tube function:physiology,pathophysiology,and role of allergy in pathogenesis of otitis media / J Allergy Clin Immunol 72 (3) : 242 ~ 251
Chabot S / 2003 / Surfactant protein A inhibits lipopolysaccharide-induced in vivo production of interleukin-10 by mononuclear phagocytes during lung inflammation / Am J Res
Chandrasekhar SS / 2002 / Intranasal metered dose aerosolized surfactant reduces passive opening pressure of the eustachian tube:comparison study in two animal models / Otol
Chandrasekhar SS / 2004 / Otitis media:treatment with intranasal aerosolized surfactant / Laryngoscope 114 (3) : 472 ~ 485
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