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논문 기본 정보

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학술저널
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대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제16권 제1호
발행연도
2012.1
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6 - 15 (10page)

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Purpose : The objective of this study was to develop background gradient correction method using excitation pulse profile compensation for accurate fat and T2* quantification in the liver. Materials and Methods: In liver imaging using gradient echo, signal decay induced by linear background gradient is weighted by an excitation pulse profile and therefore hinders accurate quantification of T2* and fat. To correct this, a linear background gradient in the slice-selection direction was estimated from a B0 field map and signal decays were corrected using the excitation pulse profile. Improved estimation of fat fraction and T2* from the corrected data were demonstrated by phantom and in vivo experiments at 3 Tesla magnetic field. Results: After correction, in the phantom experiments, the estimated T2* and fat fractions were changed close to that of a well-shimmed condition while, for in vivo experiments, the background gradients were estimated to be up to approximately 120 μT/m with increased homogeneity in T2* and fat fractions obtained. Conclusion: The background gradient correction method using excitation pulse profile can reduce the effect of macroscopic field inhomogeneity in signal decay and can be applied for simultaneous fat and iron quantification in 2D gradient echo liver imaging.

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