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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 177 - 182 (6page)
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This study examined the effects of zerumbone on monocyte migration. Monocytes are recognized as important mediators of various inflammatory diseases, and the possibility of controlling inflammatory diseases by regulating the monocyte functions, such as activity and mobility, has been reported. MCP-1, which is a chemokine with levels that increase upon inflammation, causes the migration of the monocyte cell line, THP-1. Migration occurred at a concentration of 10 ng/mL MCP-1, and the highest migration occurred at 100 ng/mL and 200 ng/mL. MCP-1-induced THP-1 migration decreased by more than 40% in the presence of zerumbone. The concentration of cAMP, an important secondary messenger of the CCR2 signaling pathway, the MCP-1 receptor, was increased in the culture medium after a zerumbone treatment. The concentrations of cAMP decreased significantly under the MCP-1 treatment condition only. On the other hand, an increase in cAMP was observed when zerumbone and MCP-1 were treated simultaneously. Erk phosphorylation induced by an MCP-1 treatment was also found to decrease with the zerumbone treatment. This study introduces the possibility of controlling inflammatory diseases through the function of zerumbone, which regulates the migration of monocytes.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Gautier EL / 2009 / Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis / Artherioscler Thromb Vasc Biol 29:1412~1418
Murakami A / 2006 / Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells / Biol Chem 387:387~392
Sulaiman MR / 2010 / Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice / Fitoterapia 81:855~858
Perimal EK / 2011 / Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways / Basic Clin Pharmacol Toxico l108:155~162
Keong YS / 2010 / Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet / Pak J Pharm Sci 23:75~82
Murakami A / 2006 / Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells / Biol Chem 387:387~392
Sulaiman MR / 2010 / Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice / Fitoterapia 81:855~858
Perimal EK / 2011 / Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways / Basic Clin Pharmacol Toxico l108:155~162
Keong YS / 2010 / Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet / Pak J Pharm Sci 23:75~82
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