지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 57 - 70 (14page)
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초록· 키워드
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The purpose of this study was to investigate the protective effects of the modified live vaccines against canine Bordetella bronchiseptica(Bb) and canine parainfluenza virus(CPIV) in puppies by nasal administration. A total of 24 puppies were classified as 3 groups consisting of 8, and each one was divided into two subgroups; vaccinated (n=4) and unvaccinated(n=4). Group I, group II and group III were challenged with Bb, CPIV, and Bb+CPIV, respectively. In group I vaccinated puppies(n=4) were experimentally challenged with Bb 2 weeks after vaccination and unvaccinated puppies(n=4) were experimentally challenged with Bb alone. The same methods of the above were applied for group II and group III. We carried out several studies including serum tests, isolation, and histopathological examination. The vaccinated puppies showed higher antibody titers than unvaccinated puppies and the titer sustained during the experimental period. In the isolation test, recovery period was shorter in the vaccinated subgroup than in the other. In clinical signs, the unvaccinated puppies showed the typical signs of tracheobronchitis (coughing, nasal and occular discharge), but another subgroup showed delayed incidence and mild clinical signs. The typical gross lesions and histopathological findings were observed in the unvaccinated puppies. In immunohistochemical findings, the vaccinated puppies showed little intensive in reaction for CPIV antigen than the other. It could be concluded that intranasal vaccination of modified live Bb and CPIV vaccine to puppies is effective to prevent canine infectious tracheobronchitis.
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참고문헌 (19)
참고문헌 신청
Appel MJ / 1970 / SV-5? like parainfluenza virus in dogs / J Am Vet Med Assoc 156 (12) : 1778 ~ 1781
Bemis DA / 1977 / Pathogenesis of canine borde?tellosis / J Infect Dis 135 (5) : 753 ~ 762
Bey RF / 1981 / Intranasal vaccination of dogs with live avirulent Bordetella bronchiseptica: Correlation of serum agglutination titer and the formation of secretary IgA wit
Binn LN / 1967 / Viruses recovered from laboratory dogs with respiratory diseases / Proc Soc Exp Biol Med 126 (1) : 140 ~ 145
Binn LN / 1968 / Upper respiratory disease in military dogs: Bacterial, mycoplasma, and viral studies / Am J Vet Res 29 (9) : 1809 ~ 1815
Bemis DA / 1977 / Pathogenesis of canine borde?tellosis / J Infect Dis 135 (5) : 753 ~ 762
Bey RF / 1981 / Intranasal vaccination of dogs with live avirulent Bordetella bronchiseptica: Correlation of serum agglutination titer and the formation of secretary IgA wit
Binn LN / 1967 / Viruses recovered from laboratory dogs with respiratory diseases / Proc Soc Exp Biol Med 126 (1) : 140 ~ 145
Binn LN / 1968 / Upper respiratory disease in military dogs: Bacterial, mycoplasma, and viral studies / Am J Vet Res 29 (9) : 1809 ~ 1815
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