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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 217 - 224 (8page)
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초록· 키워드
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Purpose: In this study, we compared the clinical efficacy of JOINS (SKI306X, SK Chemicals) with placebo on cartilage protection using magnetic resonance imaging (MRI).Materials and Methods: Sixtynine patients were randomized to the JOINS group (200 mg, three times daily for 1 year; n=33) or the placebo group (n=36). Changes in cartilage volume and thickness were measured using MRI. Changes in the delayed gadoliniumenhanced MRI of cartilage (dGEMRIC) index, subchondral bone marrow abnormality scores, and clinical scores including knee pain visual analog scale (VAS) score and Korean Western Ontario and McMaster Universities Osteoarthritis Index (KWOMAC) were also evaluated.Results: Changes in cartilage thickness and volume and subarticular bone marrow abnormality scores were not different between groups. Changes in the dGEMRIC index in the lateral tibial plateau were greater in the JOINS group than in the placebo group (19.64±114.33 msec vs. –57.77±123.30 msec; p=0.011). Significantly greater changes in VAS were observed in the JOINS group than in the placebo group (–26.00±12.25 vs. –12.47±21.54; p=0.002) and KWOMAC (–15.42 ± 7.73 vs. –8.15±13.71; p=0.003).Conclusions: Compared with placebo, JOINS had superior clinical efficacy in regard to cartilage protection.
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참고문헌 (23)
참고문헌 신청
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Bhatia D / 2013 / Current interventions in the management of knee osteoarthritis / J Pharm Bioallied Sci 5 : 30 ~ 38
Bruyere O / 2007 / Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis / Drugs Aging 24 : 573 ~ 580
Bruyere O / 2014 / An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally : a report from a task force of the European Society fo
Cameron M / 2009 / Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: rheumatoid arthritis / Phytother Res 23 : 1647 ~ 1662
Bhatia D / 2013 / Current interventions in the management of knee osteoarthritis / J Pharm Bioallied Sci 5 : 30 ~ 38
Bruyere O / 2007 / Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis / Drugs Aging 24 : 573 ~ 580
Bruyere O / 2014 / An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally : a report from a task force of the European Society fo
Cameron M / 2009 / Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: rheumatoid arthritis / Phytother Res 23 : 1647 ~ 1662
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