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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 112 - 117 (6page)
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초록· 키워드
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Purpose: The incidence of acute poststreptococcal glomerulonephritis (APSGN) in Korea has changed. This study aimed to evaluate the epidemiological and clinical changes of APSGN observed in a single Korean institution over two decades.
Methods: We retrospectively analyzed the data of 99 children (0-15 years of age) who were admitted to our institution with APSGN between 1987 and 2013. The patients were selected based on the depression of serum complement 3 (C3, <70 mg/dL) and elevated titer of antistreptolysin O (ASO, >250 IU/dL) as evidence of previous streptococcal infection.
Results: In the 99 patients, the mean age was 8.3 ± 2.7 years, and the male-tofemale ratio was 2.2:1 (66:30). The annual number of cases fluctuated markedly, and most cases were observed during the late autumn and winter months.
However, there have been few cases reported in the past 5 years. Clinical manifestations at presentation, including hypertension and generalized oedema, and the duration of hospitalization were higher and longer in patients admitted during the first half of the study period than during the most recent half-period, suggesting a more severe clinical course in the former group.
Conclusions: APSGN has become a rare disease in Korea with a trend towards a less severe clinical course. This finding suggests that the prevalence of infection-related immune-mediated diseases could change over-time, together with environmental and possibly pathogen-host relationship changes.
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참고문헌 (25)
참고문헌 신청
Bai SK / 1973 / Clinical follow-up studies on acute glomerulonephritis 220 cases / J Korean Pediatr Soc 16 : 305 ~ 313
Berrios X / 2004 / Poststreptococcal acute glomerulonephritis in Chile; 20 years of experience / Pediatr Nephrol 19 : 306 ~ 312
Coppo R / 1998 / Frequency of renal diseases and clinical indications for renal biopsies in children:Report of the Italian National registry of Renal Biopsies in Children / N
Fish AJ / 1970 / Epidemic glomerulonephritis assoc
Flores AR / 2014 / Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production / Infect Immun 82 : 3958 ~ 3967
Berrios X / 2004 / Poststreptococcal acute glomerulonephritis in Chile; 20 years of experience / Pediatr Nephrol 19 : 306 ~ 312
Coppo R / 1998 / Frequency of renal diseases and clinical indications for renal biopsies in children:Report of the Italian National registry of Renal Biopsies in Children / N
Fish AJ / 1970 / Epidemic glomerulonephritis assoc
Flores AR / 2014 / Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production / Infect Immun 82 : 3958 ~ 3967
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