지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 60 - 69 (10page)
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초록· 키워드
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Background/Aims: Identifying the impact of a patient’s ethnicity on treatment responses in clinical practice may assist in providing individualized treatment regimens for chronic hepatitis C (CHC). The effectiveness of standard peginterferon plus ribavirin therapy and the need for triple combination therapy with protease inhibitors in Koreans remain matters of debate. These issues were investigated in the present study.
Methods: The clinical data of 272 treatment-naïve Korean CHC patients who were treated in a community-based clinical trial (Clinical Trial group; n=51) and in clinical practice (Cohort group; n=221), were analyzed and compared. All were treated with standard protocols of peginterferon alfa-2a plus ribavirin therapy.
Results: For patients with hepatitis C virus (HCV) genotype 1, the sustained virological response (SVR) rates in the Clinical Trial and Cohort groups were 81% (21/26) and 55% (58/106), respectively, by intention-to-treat (ITT) analysis (P=0.02), and 100% (13/13) and 80% (32/40), respectively, in treatment-adherent patients (P=0.18). For patients with HCV genotype 2,the SVR rates in these two groups were 96% (24/25) and 88% (101/115), respectively, by ITT analysis (P=0.31). Adherence and treatment duration were independent predictors of SVR for genotypes 1 and 2, respectively (P<0.01 for each). Korean patients with CHC achieved high SVR rates with peginterferon alfa-2a plus ribavirin in both the clinical trial and clinical practice settings.
Conclusions: Measures to raise adherence to standard therapy in clinical practice may improve the SVR rates in these patients as effectively as adding protease inhibitors, thus obviating the need for the latter. (Clin Mol Hepatol 2013;19:60-69)
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참고문헌 (37)
참고문헌 신청
Lo Re V 3rd / 2011 / Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study / Ann Intern Med 155:353~360
Marotta P / 2009 / Efficacy of chronic hepatitis C therapy in community-based trials / Clin Gastroenterol Hepatol 7:1028~1036
Howell CD / 2012 / Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1 / J Hepatol 56:557~563
Sinn DH / 2011 / Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in Asian patients / J Gastroenterol Hepatol 26:1374~1379
Lyoo K / 2011 / Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg-interferon plus ribavirin / J Clin Virol 52:363~366
Marotta P / 2009 / Efficacy of chronic hepatitis C therapy in community-based trials / Clin Gastroenterol Hepatol 7:1028~1036
Howell CD / 2012 / Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1 / J Hepatol 56:557~563
Sinn DH / 2011 / Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in Asian patients / J Gastroenterol Hepatol 26:1374~1379
Lyoo K / 2011 / Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg-interferon plus ribavirin / J Clin Virol 52:363~366
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