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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 365 - 371 (7page)
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초록· 키워드
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Background/Aims: Ascites is a dreadful complication of liver cirrhosis associated with short survival. Large volume paracentesis (LVP) is used to treat tense or refractory ascites. Paracentesis induced circulatory dysfunction (PICD) develops if no plasma expanders are given with ominous complications. To study the effect of ascites flow rate on PICD development.
Methods: Sixty patients with cirrhosis and tense ascites underwent LVP of 8 L were randomized into 3 equal groups of different flow rate extraction; group I (80 mL/minute), group II (180 mL/minute) and group III (270 mL/minute). Plasma renin activity (PRA) was measured baseline and on day six. PICD was defined as increase in PRA >50% of the pretreatment value.
Results: In group I through 3; the mean age was (52.5±9.4 vs. 56.4±8.5 vs. 55.8±7.1 years; P>0.05), mean arterial pressure (81.4±5.6 vs. 81.5±7 vs. 79.5±7.2 mmHg; P>0.05), MELD (17.6±4.1 vs. 15.8±4.1 vs. 14.7±4.5). Baseline PRA was comparable (1,366.0±1244.9 vs. 1,151.3±1,444.8 vs. 951.9±1,088 pg/mL; P>0.05). There was no statistically significant (P>0.05) flow mediated changes (Δ) of creatinine (0.23±0.27 vs. 0.38±0.33 vs. 0.26±0.18 mg/dL), MELD (1.25±5.72 vs. 1.70±2.18 vs. 1.45±2.21) or PRA (450.93±614.10 vs. 394.61±954.64 vs. 629.51±1,116.46 pg/mL). PICD was detected in a similar frequency in the three groups (P>0.05). On univariate logistic analysis only female sex was a fairly significant PICD predictor (Wald 3.85, odds ratio 3.14; P=0.05).
Conclusions: The ascites flow rate does not correlate with PICD development.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Abdullah MH / 2012 / Terlipressin versus norepinephrine to counteract intraoperative paracentesis induced refractory hypotension in cirrhotic patients / Egyptian J Anaesthes
Alessandria C / 2011 / Prevention of paracentesis-induced circulatory dysfunction in cirrhosis: standard vs half albumin doses. A prospective, randomized, unblinded pilot st
Alsebaey A / 2013 / Prevention of paracentesis-induced circulatory dysfunction: could we use other albumin alternatives? / Egyptian Liver J 3 : 118 ~ 125
Appenrodt B / 2008 / Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study / Liver Int 28 : 1019 ~ 1025
European Association for the Study of the Liver / 2010 / EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal sy
Alessandria C / 2011 / Prevention of paracentesis-induced circulatory dysfunction in cirrhosis: standard vs half albumin doses. A prospective, randomized, unblinded pilot st
Alsebaey A / 2013 / Prevention of paracentesis-induced circulatory dysfunction: could we use other albumin alternatives? / Egyptian Liver J 3 : 118 ~ 125
Appenrodt B / 2008 / Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study / Liver Int 28 : 1019 ~ 1025
European Association for the Study of the Liver / 2010 / EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal sy
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