지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 17 - 27 (11page)
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Background: Angiotensin II (AngII) and abnormal oscillatory shear stress are highly associated with vascular inflammation including atherosclerosis. However, it is poorly understood how interactions between AngII and shear stress in human aortic endothelial cells (HAEC) are involved in mechanisms by which cellular adhesion molecules are expressed. The purpose of this study was to improve that understanding. Methods: AngII (10^-7M for 6 hr) and two-types of shear stress treatments were used: laminar shear stress (LS: unidirectional, 12 dynes/cm^2) and oscillatory shear stress (OS: bi-directional, 5 dynes/cm^2, 1Hz) in HAEC. Immunoblotting was used to detect expression of cellular adhesion molecules markers such as vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1). Results: AngII significantly increased VCAM1 and ICAM1 expression in HAEC that had been reduced due to pretreatment with telmisartan. AngII-LS co-stimulation and AngII-OS co-stimulation significantly increased VCAM1 and ICAM1 expression in HAEC. The expression levels of VCAM1 and ICAM1 were also, significantly reduced when pretreated with telmisartan. However, VCAM1 and ICAM1 expression were significantly reduced under LS and OS stimulation. Conclusions: Telmisartan may modulate the expressions of VCAM1 and ICAM1 via different types of shear stress in HAEC that are activated by AngII.
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참고문헌 (24)
참고문헌 신청
Ando J / 1994 / stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression / American Journal of Physiology 267 : 679 ~ 6
Berliner JA / 1995 / Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics / Circulation 91 : 2488 ~ 2496
Catt KJ / 1984 / The role of angiotensin II receptors in vascular regulation / Journal of Cardiovascular Pharmacology 6 (4) : 575 ~ 586
Choi SH / 2009 / Effects of angiotensin II receptor blockers on endothelial progenitor cells in spontaneously hypertensive ra / Journal of the Korean Society of Hypertension
Cunningham KS / 2005 / The role of shear stress in the pathogenesis of atherosclerosis / Laboratory Investigation 85 : 9 ~ 23
Berliner JA / 1995 / Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics / Circulation 91 : 2488 ~ 2496
Catt KJ / 1984 / The role of angiotensin II receptors in vascular regulation / Journal of Cardiovascular Pharmacology 6 (4) : 575 ~ 586
Choi SH / 2009 / Effects of angiotensin II receptor blockers on endothelial progenitor cells in spontaneously hypertensive ra / Journal of the Korean Society of Hypertension
Cunningham KS / 2005 / The role of shear stress in the pathogenesis of atherosclerosis / Laboratory Investigation 85 : 9 ~ 23
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