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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
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Introduction: The present study was designed to examine whether methylene chloride (CH2Cl2) fraction extracted from Rubus coreanum affects the contractility of the isolated thoracic aortic strips and blood pressure of normotensive rats.
Methods: One of the common carotid arteries or of the femoral arteries was catheterized with a polyethylene tubing. The tubing was connected to a pressure transducer, and pulse of the mean arterial blood pressure was recorded on a biological polygraph continuously.
Results: The CH2Cl2 fraction (range, 200 to 800 μg/mL) significantly depressed both phenylephrine (PE, 10 μM)- and high K+ (56 mM)-induced contractile responses of the isolated thoracic aortic strips in a concentration-dependent fashion. In the simultaneous presence of Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) (an inhibitor of nitric oxide [NO] synthase, 300 μM) and the CH2Cl2 fraction (400 μg/mL), both PE- and high K+-induced contractile responses were recovered to the significant level of the corresponding control response in comparison with inhibition of CH2Cl2 fraction treatment alone. Moreover, in the simultaneous presence of the CH2Cl2 fraction after pretreatment with 0.4% CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propane sulfonate), both PE- and high K+-induced contractile responses were recovered to the significant level of the corresponding control response compared to the inhibitory response of CH2Cl2 fraction treatment alone. Also, in anesthetized rats, the CH2Cl2 fraction (range, 0.3 to 3.0 mg/kg) injected into a femoral vein dose-dependently produced depressor responses. This hypotensive action of the CH2Cl2 fraction was greatly inhibited after treatment with phentolamine (1 mg/kg), chlorisondamine (1 mg/kg), L-NAME (3 mg/kg/30 min), or sodium nitroprusside (30 μg/kg/30 min). Intravenous infusion of the CH2Cl2 fraction (range, 1.0 to 10.0 mg/kg/30 min) markedly inhibited norepinephrine-induced pressor responses.
Discussion: Taken together, these results demonstrate that the CH2Cl2 fraction causes vascular relaxation in the isolated rat thoracic aortic strips as well as hypotensive action in anesthetized rats. These vasorelaxation and hypotension of the CH2Cl2 fraction seem to be mediated at least by the increased NO production through the activation of NO synthase of the vascular endothelium and the inhibitory adrenergic modulation.
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참고문헌 (22)
참고문헌 신청
Andriambeloson E / 1999 / Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta / J Cardiovasc Pharmacol 33 : 248 ~
Bernatova I / 2002 / Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension / Am J Physiol Heart Circ Physiol 282 : H942 ~ H94
Bouloumie A / 1997 / Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production / Hypertension 30 : 934 ~ 941
Byung-Sik YU / 2008 / Inhibitory Mechanism of Polyphenol Compounds Isolatedfrom Red Wine on Catecholamine Release in thePerfused Rat Adrenal Medulla / Biomolecules & Ther
Corder R / 2001 / Endothelin-1 synthesis reduced by red wine / Nature 414 : 863 ~ 864
Bernatova I / 2002 / Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension / Am J Physiol Heart Circ Physiol 282 : H942 ~ H94
Bouloumie A / 1997 / Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production / Hypertension 30 : 934 ~ 941
Byung-Sik YU / 2008 / Inhibitory Mechanism of Polyphenol Compounds Isolatedfrom Red Wine on Catecholamine Release in thePerfused Rat Adrenal Medulla / Biomolecules & Ther
Corder R / 2001 / Endothelin-1 synthesis reduced by red wine / Nature 414 : 863 ~ 864
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