지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 162 - 167 (6page)
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초록· 키워드
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Purpose: Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding. Various doses of methylphenidate were investigated for their effects on cystometric parameters in conscious mice.
Methods: Ten male C57BL/6 mice, weighing between 20 and 23 g, were used in this study. To compare the acute drug responses before and after the oral medication was administered in the awake condition, we injected the solution through a catheter inserted into the stomach. Methylphenidate (1.25, 2.5, and 5 mg/kg) in an injection volume of 0.05 mL was administered.
Results: Four mice that received high doses of methylphenidate (2.5 and 5 mg/kg) showed no voiding contraction, with urine leakage. Six mice that received a low dose of methylphenidate (1.25 mg/kg) showed typical micturition cycles before and after administration. The micturition pressure decreased and bladder capacity increased without an increased residual volume after administration.
Conclusions: Methylphenidate has differential, dose-dependent effects on the function of the lower urinary tract, due to the dependent relationship between the brain and lower urinary tract. Especially at higher doses, this drug may interfere with normal micturition. Therefore, more detailed clinical or experimental studies are warranted in the future.
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참고문헌 (24)
참고문헌 신청
Agster KL / 2011 / Experimental strategies for investigating psychostimulant drug actions and prefrontal cortical function in ADHD and related attention disorders / Anat Rec
Andersson KE / 2004 / Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence / Pharmacol Rev 56 : 581 ~ 631
Berry AK / 2009 / Methylphenidate for giggle incontinence / J Urol 182 (4 Suppl) : 2028 ~ 2032
Biederman J / 2004 / Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder / Int J Neuropsychopharmacol 7 : 77 ~ 97
Blok BF / 1999 / Two pontine micturition centers in the cat are not interconnected directly: implications for the central organization of micturition / J Comp Neurol 403 : 2
Andersson KE / 2004 / Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence / Pharmacol Rev 56 : 581 ~ 631
Berry AK / 2009 / Methylphenidate for giggle incontinence / J Urol 182 (4 Suppl) : 2028 ~ 2032
Biederman J / 2004 / Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder / Int J Neuropsychopharmacol 7 : 77 ~ 97
Blok BF / 1999 / Two pontine micturition centers in the cat are not interconnected directly: implications for the central organization of micturition / J Comp Neurol 403 : 2
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