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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제55권 제5호
발행연도
2014.1
수록면
1,177 - 1,186 (10page)

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This study was performed to review studies carried out in Korea reporting toxic reactionsto traditional Chinese medicines (TCMs) as a result of heavy metal contamination. PubMed (1966--August 2013) and International Pharmaceutical Abstracts (1965--August 2013) were searched using the medical subject heading terms of “Medicine, Chinese Traditional,” “Medicine, Korean Traditional,” “Medicine, Traditional,”“Metals, Heavy,” and “Drug Contamination”. For Korean literature, KoreaMed (http://www.koreamed.org), the Korean Medical Database (http://kmbase.medric.or.kr), National Discovery for Science Leaders (www.ndsl.kr), Research InformationSharing Service (http://www.riss.kr), and Google Scholar were searched using the terms “Chinese medicine,” “Korean medicine,” “herbal medicine,” and “metallic contamination” in Korean. Bibliographies of case reports and case series, identified using secondary resources, were also utilized. Only literature describing cases or studies performed in Korea were included. Case reports identified clear issueswith heavy metal, particularly lead, contamination of TCMs utilized in Korea. No international standardization guidelines for processing, manufacturing and marketingof herbal products exist. Unacceptably high levels of toxic metals can be present in TCM preparations. Health care providers and patients should be educated on the potential risks associated with TCMs. International advocacy for stricter standardization procedures for production of TCMs is warranted.

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