지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,214 - 1,221 (8page)
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Purpose: We investigated sex-hormone receptor expression as predicting factor of recurrence and progression in patients with non-muscle invasive bladder cancer. Materialsand Methods: We retrospectively evaluated tumor specimens from patients treated for transitional cell carcinoma of the bladder at our institution between January2006 and January 2011. Performing immunohistochemistry using a monoclonal androgen receptor antibody and monoclonal estrogen receptor-beta antibody on paraffin-embedded tissue sections, we assessed the relationship of immunohistochemistryresults and prognostic factors such as recurrence and progression. Results: A total of 169 patients with bladder cancer were evaluated in this study. Sixty-threepatients had expressed androgen receptors and 52 patients had estrogen receptor beta. On univariableanalysis, androgen receptor expression was significant lower in recurrence rates (p=0.001), and estrogen receptor beta expression was significant higher in progressionrates (p=0.004). On multivariable analysis, significant association was found between androgen receptor expression and lower recurrence rates (hazard ratio=0.500; 95% confidence interval, 0.294 to 0.852; p=0.011), but estrogen receptor beta expression was not significantly associated with progression rates. Conclusion: We concluded that the possibility of recurrence was low when the androgen receptor was expressed in the bladder cancer specimen and it could be the predicting factor of the stage, number of tumors, carcinoma in situ lesion and recurrence.
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참고문헌 (33)
참고문헌 신청
Kaufmann O / 1998 / Detection of oestrogen receptors in non-invasive and invasive transitional cell carcinomas of the urinary bladder using both conventional immunohistochemistry and the tyramide staining amplification (TSA) technique / J Pathol 186:165~168
Kvist E / 1994 / Oestrogen receptor investigations in bladder tumours / Scand J Urol Nephrol 28:369~370
Boorjian S / 2004 / Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer / Urology 64:383~388
Kontos S / 2010 / Inverse expression of estrogen receptor-beta and nuclear factor-kappaB in urinary bladder carcinogenesis / Int J Urol 17:801~809
Croft PR / 2005 / Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma / Arch Pathol Lab Med 129:194~199
Kvist E / 1994 / Oestrogen receptor investigations in bladder tumours / Scand J Urol Nephrol 28:369~370
Boorjian S / 2004 / Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer / Urology 64:383~388
Kontos S / 2010 / Inverse expression of estrogen receptor-beta and nuclear factor-kappaB in urinary bladder carcinogenesis / Int J Urol 17:801~809
Croft PR / 2005 / Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma / Arch Pathol Lab Med 129:194~199
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