지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,289 - 1,296 (8page)
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Purpose: This study aimed to assess the role of thiopurine S-methyltransferase (TPMT) and 6-thioguanine nucleotide (6-TGN) as predictors of clinical response and side effects to azathioprine (AZA), and estimate the optimal AZA dose in Koreanpediatric inflammatory bowel disease (IBD) patients. Materials and Methods:One hundred and nine pediatric IBD patients in whom AZA treatment was requiredwere enrolled. Thiopurine metabolites were monitored since September 2010. Among them, 83 patients who had prescribed AZA for at least 3 months priorto September 2010 were enrolled and followed until October 2011 to evaluate optimal AZA dose, adverse effects and disease activity before and after thiopurine metabolite monitoring. Results: The result of the TPMT genotype was that 102 patients were *1/*1 (wild type), four were *1/*3C, one was *1/*6, one was *1/*16 (heterozygote) and one was *3C/*3C (homozygote). Adverse effects happened in 31 patients pre-metabolite monitoring and in only nine patients post-metabolite monitoring. AZA dose was 1.4±0.31 mg/kg/day before monitoring and 1.1±0.46 mg/kg/day after monitoring (p<0.001). However, there were no statistical differencesin disease activity during metabolite monitoring period (p=0.34). Adverse effects noticeably decreased although reduction of the AZA dose since monitoring. Conclusion: TPMT genotype and thiopurine metabolite monitoring could be helpfulto examine TPMT genotypes before administering AZA and to measure 6-TGN concentrations during prescribing AZA in IBD patients.
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참고문헌 (21)
참고문헌 신청
Cao Q / 2009 / Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease / Digestion 79 : 58 ~ 63
Cuffari C / 2001 / Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease / Gut 48 : 642 ~ 64
Cuffari C / 2004 / Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease / Clin Gastroenterol Hepatol 2 : 410 ~ 41
Derijks LJ / 2006 / Review article: thiopurines in inflammatory bowel disease / Aliment Pharmacol Ther 24 : 715 ~ 729
Dorababu P / 2012 / Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine
Cuffari C / 2001 / Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease / Gut 48 : 642 ~ 64
Cuffari C / 2004 / Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease / Clin Gastroenterol Hepatol 2 : 410 ~ 41
Derijks LJ / 2006 / Review article: thiopurines in inflammatory bowel disease / Aliment Pharmacol Ther 24 : 715 ~ 729
Dorababu P / 2012 / Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine
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