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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제57권 제5호
발행연도
2016.1
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1,178 - 1,184 (7page)

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Purpose: To investigate the clinical and morphological characteristics in relation to risk of bifurcation intracranial aneurysm rupture. Materials and Methods: Data from 202 consecutive patients with 219 bifurcation aneurysms (129 ruptured and 90 unruptured) managed at the authors’ facility between August 2011 and July 2014 were retrospectively reviewed. Based on their clinical records and CT angiographic findings, the ability of risk factors to predict aneurysm rupture was assessed using statistical methods. Results: Age, hypertension, diabetes mellitus, and cerebral atherosclerosis were negatively correlated with aneurysm rupture. Aneurysms located in the middle cerebral artery, daughter artery ratio, lateral angle ratio (LA ratio), and neck width were negativelycorrelated with rupture. Aneurysms located in the anterior communicating artery, irregularity, with daughter sac, depth, width, maximum size, aspect ratio (AR), depth-to-width ratio, and bottleneck factor were significantly and positively correlated with rupture. Binary logistic regression model revealed that irregular shape [odds ratio (OR) 6.598] and AR (OR 3.507) strongly increasedthe risk of bifurcation aneurysm rupture, while age (OR 0.434), cerebral atherosclerosis (OR 0.125), neck width (OR 0.771), and LA ratio (OR 0.267) were negatively correlated with rupture (p<0.05). Receiver operating characteristic analysis revealedthe threshold values of AR and LA ratio to be 1.18 and 1.50, respectively. Conclusion: Age (≥60 yr), cerebral atherosclerosis, and aneurysms with a larger neck width and larger LA ratio are protective factorsagainst bifurcation aneurysm rupture. An aneurysm with an irregular shape and an increased AR reflect the greater likelihoodof a rupture.

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