지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,152 - 1,158 (7page)
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초록· 키워드
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Purpose: We report our initial experience with transurethral injection of autologous adipose-derived regenerative cells (ADRCs) for the treatment of urinary incontinence after radical prostatectomy.
Materials and Methods: After providing written informed consent, six men with persistent urinary incontinence after radical prostatectomy were enrolled in the study. Under general anesthesia, about 50 mL of adipose tissue was obtained from the patients by liposuction. ADRCs were obtained by separation with centrifugation using the Celution cell-processing device. A mixture of ADRCs and adipose tissue were transurethrally injected into the submucosal space of the membranous urethra. Functional and anatomical improvement was assessed using a 24-h pad test, validated patient questionnaire, urethral pressure profile, and magneticresonance imaging (MRI) during 12-week follow-up.
Results: Urine leakage volume was improved with time in all patients in the 24-h pad test, with the exemption of temporal deteriorationat the first 2 weeks post-injection in 2 patients. Subjective symptoms and quality of life assessed on the basis of questionnaireresults showed similar improvement. The mean maximum urethral closing pressure increased from 44.0 to 63.5 cm H2O at 12 weeks after injection. MRI showed an increase in functional urethral length (from 6.1 to 8.3 mm) between the lower rim of the pubicbone and the bladder neck. Adverse events, such as pelvic pain, inflammation, or de novo urgency, were not observed in any case during follow-up.
Conclusion: This study demonstrated that transurethral injection of autologous ADRCs can be a safe and effective treatment modalityfor postprostatectomy incontinence.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bauer RM / 2009 / Postprostatectomy incontinence: all about diagnosis and management / Eur Urol 55:322~333
Clemens JQ / 2001 / Revision rate after artificial urinary sphincter implantation for incon-tinence after radical prostatectomy: actuarial analysis / J Urol 166:1372~1375
Giberti C / 2013 / Stem cell therapy for male urinary incontinence / Urol Int 90:249~252
Kinebuchi Y / 2010 / Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter / Int J Urol 17:359~368
Zhao W / 2011 / Periurethral injection of autologous adipose-derived stem cells with controlledrelease nerve growth factor for the treatment of stress urinary incontinence in a rat model / Eur Urol 59:155~163
Clemens JQ / 2001 / Revision rate after artificial urinary sphincter implantation for incon-tinence after radical prostatectomy: actuarial analysis / J Urol 166:1372~1375
Giberti C / 2013 / Stem cell therapy for male urinary incontinence / Urol Int 90:249~252
Kinebuchi Y / 2010 / Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter / Int J Urol 17:359~368
Zhao W / 2011 / Periurethral injection of autologous adipose-derived stem cells with controlledrelease nerve growth factor for the treatment of stress urinary incontinence in a rat model / Eur Urol 59:155~163
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