지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 183 - 188 (6page)
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Purpose: Our aim was to determine the effects of infliximab on bone mineral metabolism in rheumatoid arthritis (RA) patients and analyze the relationship between inflammatory markers of acute phase thought to play a major role in bone remodeling. Materials and Methods: 36 patients with established RA were investigated.
All patients underwent physical examination and blood and urinary analysis at baseline, 2 weeks, 14 weeks, 6 months and 12 months after the initiation of treatment. The serum levels of: tumor necrosis factor alpha (TNF-alpha), tumor necrosis factor alpha receptor 1 (TNFR1), TNFR2, interleukin 6 (IL-6), IL-17, IL-23 and markers of bone remodeling such as osteocalcin (BGP), deoxypyridynoline (Dpd), and N-telopeptide of type I collagen (NTx) were measured by ELISA. Results: The results showed significant decrease of all the above cytokines levels in RA patients in comparison with those after 2 weeks of treatment.
After 6 months, the markers of bone formation and resorption decreased compared to baseline values. We found positive correlation between the levels of NTx and the levels of IL-6, IL-17 and TNFR1, and between the levels of Dpd and IL-6 and Dpd and TNFR2, whereas negative correlation between BGP and IL-23. After 12 months the positive association was found at the BGP level and IL-6 as well as Dpd and the level of IL-6. We also observed a positive relation between Dpd and TNF-alpha and negative between BGP and TNFR1. Conclusion:We suggest that infliximab treatment may limit the risk of osteoporosis in RA patients.
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참고문헌 (23)
참고문헌 신청
Choy EH / 2001 / Cytokine pathways and joint inflammation in rheumatoid arthritis / N Engl J Med 344 : 907 ~ 916
Greenspan SL / 1998 / Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomiz
Kageyama Y / 2007 / Treatment with anti-TNF-alpha antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis / Clin Rheumatol 26 : 505 ~ 509
Kageyama Y / 2009 / Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis / Mod Rheumatol 19 : 657 ~ 662
Kelchtermans H / 2009 / Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma / Arthrit
Greenspan SL / 1998 / Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomiz
Kageyama Y / 2007 / Treatment with anti-TNF-alpha antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis / Clin Rheumatol 26 : 505 ~ 509
Kageyama Y / 2009 / Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis / Mod Rheumatol 19 : 657 ~ 662
Kelchtermans H / 2009 / Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma / Arthrit
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