지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 113 - 117 (5page)
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Purpose: To evaluate the diagnostic performance of maternal inflammatory marker:C-reactive protein (CRP) in predicting early onset neonatal sepsis (that occurring within 72 hours after birth). Materials and Methods: 126 low birth weight newborns (gestation 32±3.2 wk, birth weight 1887±623 g) and their mothers were included. Neonates were divided into sepsis group (n=51) including both proven (positive blood culture) and suspected (negative blood culture but with more than 3 abnormal clinical signs), and controls (n=75). Mothers were subgrouped into CRP positive ≥1.22 mg/dL (n=48) and CRP negative <1.22 mg/dL (n=78) group, determined by Receiver Operating Characteristic curves, and odds ratio was calculated for neonatal sepsis according to maternal condition. Results: Maternal CRP was significantly higher in neonatal sepsis group than in control (3.55±2.69 vs. 0.48±0.31 mg/dL, p=0.0001). Maternal CRP (cutoff value >1.22 mg/dL) had sensitivity 71% and specificity 84% for predicting neonatal sepsis. Maternal CRP positive group had more neonatal sepsis than CRP negative group (71% vs. 29%, p<0.001). Odds ratio of neonatal sepsis in maternal CRP positive group versus CRP negative group was 10.68 (95% confidence interval: 4.313-26.428, p<0.001). Conclusion: The risk of early onset neonatal sepsis significantly increased in the case of positive maternal CRP (≥1.22 mg/dL). In newborn of CRP positive mother,the clinician may be alerted to earlier evaluation for possible neonatal infection prior to development of sepsis.
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참고문헌 (23)
참고문헌 신청
Asrat T / 2001 / Intra-amniotic infection in patients with preterm prelabor rupture of membranes. Pathophysiology, detection, and management / Clin Perinatol 28 : 735 ~ 751
Beck JR / 1986 / The use of relative operating characteristic (ROC) curves in test performance evaluation / Arch Pathol Lab Med 110 : 13 ~ 20
Bender L / 2008 / Early and late markers for the detection of early-onset neonatal sepsis / Dan Med Bull 55 : 219 ~ 223
Edmond K / 2010 / New approaches to preventing, diagnosing, and treating neonatal sepsis / PLoS Med 7 : e1000213 ~
Eschenbach DA / 1997 / Amniotic fluid infection and cerebral palsy. Focus on the fetus / JAMA 278 : 247 ~ 248
Beck JR / 1986 / The use of relative operating characteristic (ROC) curves in test performance evaluation / Arch Pathol Lab Med 110 : 13 ~ 20
Bender L / 2008 / Early and late markers for the detection of early-onset neonatal sepsis / Dan Med Bull 55 : 219 ~ 223
Edmond K / 2010 / New approaches to preventing, diagnosing, and treating neonatal sepsis / PLoS Med 7 : e1000213 ~
Eschenbach DA / 1997 / Amniotic fluid infection and cerebral palsy. Focus on the fetus / JAMA 278 : 247 ~ 248
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