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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,197 - 1,204 (8page)
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초록· 키워드
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Purpose: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerativediseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerativedisease and to broaden understanding thereof. Materials and Methods: We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. Results: We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer’s disease (AD), two with subcortical vascular dementia,two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia(FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. Conclusion: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.
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등록된 정보가 없습니다.
참고문헌 (5)
참고문헌 신청
안현정 / 2010 / Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients / Journal of Korean Medical Science 25(7):1071~1076
이경화 / 2017 / Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea / Yonsei Medical Journal 58(5):1055~1060
Boeve BF / 2003 / Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia / Ann Neurol 54(Suppl 5):S15~S19
Kim HJ / 2016 / Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories / Brain 139(Pt 9):2516~2527
Rascovsky K / 2011 / Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia / Brain 134(Pt 9):2456~2477
이경화 / 2017 / Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea / Yonsei Medical Journal 58(5):1055~1060
Boeve BF / 2003 / Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia / Ann Neurol 54(Suppl 5):S15~S19
Kim HJ / 2016 / Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories / Brain 139(Pt 9):2516~2527
Rascovsky K / 2011 / Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia / Brain 134(Pt 9):2456~2477
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