지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 63 - 70 (8page)
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초록· 키워드
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Purpose: The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). Materials and Methods: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344: 1690, 55.2±10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. Results: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (β=0.311, p<0.001), MetS score (β=0.226, p<0.001), male gender (β=-0.093, p <0.001) and HOMA index IR (β=0.033, p=0.03) are significantly associated with PP (R2=0.207, p<0.001). Conclusion: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benetos A / 1997 / Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population / Hypertension 30 : 1410 ~ 1415
Blacher J / 2000 / Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients / Arch Intern Med 160 : 1085 ~ 1089
Chobanian AV / 2003 / Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure / Hypertension 42 : 1206 ~ 12
Czernichow S / 2005 / Metabolic syndrome in relation to structure and function of large arteries: a predominant effect of blood pressure. A report from the SU.VI.MAX. Vascula
Executive Summary of The Third Report of The National Cholesterol Education Program / 2001 / Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol I
Blacher J / 2000 / Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients / Arch Intern Med 160 : 1085 ~ 1089
Chobanian AV / 2003 / Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure / Hypertension 42 : 1206 ~ 12
Czernichow S / 2005 / Metabolic syndrome in relation to structure and function of large arteries: a predominant effect of blood pressure. A report from the SU.VI.MAX. Vascula
Executive Summary of The Third Report of The National Cholesterol Education Program / 2001 / Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol I
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