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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 35 - 42 (8page)
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Purpose: Decitabine, a DNA hypomethylating agent, was recently approved for use in Korea for older adults with acute myeloid leukemia (AML) who are not candidates for standard chemotherapy. This study aimed to evaluate the role of decitabine as a first-line treatment for older adults with AML.
Materials and Methods: Twenty-four patients with AML who received at least one course of decitabine (20 mg/m2/d intravenouslyfor 5 days every 4 weeks) as a first-line therapy at Severance Hospital were evaluated retrospectively.
Results: The median age of the patients was 73.5 years. The longest follow-up duration was 502 days. A total of 113 cycles of treatmentwere given to 24 patients, and the median number of cycles was four (range, 1–14). Thirteen patients dropped out because of death, no or loss of response, patient refusal, or transfer to another hospital. Twenty-one (87.5%) and 12 (50%) patients completedthe second and fourth cycles, respectively, and responses to treatment were evaluated in 17. A complete response (CR) or CR with incomplete blood-count recovery was achieved in six (35.3%) patients, and the estimated median overall survival was 502 days. Ten patients developed grade >2 hematologic or non-hematologic toxicities. In univariate analysis, bone marrow blasts, lactate dehydrogenase, serum ferritin level, and bone marrow iron were significantly associated with response to decitabine.
Conclusion: Five-day decitabine treatment showed acceptable efficacy in older patients with AML who are unfit for conventional chemotherapy, with a CR rate 35.3% and about a median overall survival of 18 months.
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참고문헌 (29)
참고문헌 신청
Korea Central Cancer Registry NCC / 2014 / Annual report of cancer statistics in Korea in 2012
Sorm F / 1968 / Effect of 5-aza-2’-deoxycytidine against leukemic and hemopoietic tissues in AKR mice / Neoplasma 15:339~343
Issa JP / 2004 / Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2’-deoxycytidine (decitabine)in hematopoietic malignancies / Blood 103:1635~1640
Jüttermann R / 1994 / Toxicity of 5-aza-2’-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation / Proc Natl Acad Sci U S A 91:11797~11801
Cruijsen M / 2014 / Clinical results of hypomethylating agents in AML treatment / J Clin Med 4:1~17
Sorm F / 1968 / Effect of 5-aza-2’-deoxycytidine against leukemic and hemopoietic tissues in AKR mice / Neoplasma 15:339~343
Issa JP / 2004 / Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2’-deoxycytidine (decitabine)in hematopoietic malignancies / Blood 103:1635~1640
Jüttermann R / 1994 / Toxicity of 5-aza-2’-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation / Proc Natl Acad Sci U S A 91:11797~11801
Cruijsen M / 2014 / Clinical results of hypomethylating agents in AML treatment / J Clin Med 4:1~17
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