지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 221 - 225 (5page)
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초록· 키워드
오류제보하기
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they arewidely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lowerurinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetryand the International Prostate Symptom Score. A significant improvement of symptoms was observed in relationto the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animalstudies, both nonselective K+ channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increasedcontraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-APin urological symptoms in humans.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Alvina K / 2010 / The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia / J Neurosci 30 : 7258 ~ 7268
Diener HC / 1984 / Characteristic alterations of long-loop “reflexes” in patients with Friedreich’s disease and late atrophy of the cerebellar anterior lobe / J Neurol Neu
Etzion Y / 2001 / Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells / Exp Brain Res 139 : 419 ~ 42
Grijalva I / 2007 / Gastric emptying effect by 4-aminopyridine in patients with chronic spinal cord injury / Arch Med Res 38 : 392 ~ 397
Hidayat Santoso AG / 2011 / Bladder contractility is mediated by different K+ channels in the urothelium and detrusor smooth muscle / J Pharmacol Sci 115 : 127 ~ 134
Diener HC / 1984 / Characteristic alterations of long-loop “reflexes” in patients with Friedreich’s disease and late atrophy of the cerebellar anterior lobe / J Neurol Neu
Etzion Y / 2001 / Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells / Exp Brain Res 139 : 419 ~ 42
Grijalva I / 2007 / Gastric emptying effect by 4-aminopyridine in patients with chronic spinal cord injury / Arch Med Res 38 : 392 ~ 397
Hidayat Santoso AG / 2011 / Bladder contractility is mediated by different K+ channels in the urothelium and detrusor smooth muscle / J Pharmacol Sci 115 : 127 ~ 134
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