지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 321 - 329 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Lamotrigine, a novel anticonvulsant, is a sodium channel blocker that is efficacious in certain forms of neuropathic pain. Recently, microglial and astrocytic activation has been implicated in the development of nerve injury-induced neuropathic pain. We have assessed the effects of continuous intrathecal administration of lamotrigine on the development of neuropathic pain and glial activation induced by L5/6 spinal-nerve ligation in rats. Materials and Methods: Following left L5/6 spinal nerve ligation (SNL), Sprague-Dawley male rats were intrathecally administered lamotrigine (24, 72, or 240 μg/day) or saline continuously for 7 days. Mechanical allodynia of the left hind paw to von Frey filament stimuli was determined before surgery (baseline) and once daily for 7 days postoperatively. On day 7, spinal activation of microglia and astrocytes was evaluated immunohistochemically,using antibodies to the microglial marker OX-42 and the astrocyte marker glial fibrillary acidic protein (GFAP). Results: Spinal-nerve ligation induced mechanical allodynia in saline-treated rats, with OX-42 and GFAP immunoreactivity being significantly increased on the ipsilateral side of the spinal cord. Continuously administered intrathecal lamotrigine (240 μg/day) prevented the development of mechanical allodynia, and lower dose of lamotrigine (72 μg/day) ameliorated allodynia. Intrathecal lamotrigine (72 and 240 μg/day) inhibited nerve ligation-induced microglial and astrocytic activation, as evidenced by reduced numbers of cells positive for OX-42 and GFAP. Conclusion: Continuously administered intrathecal lamotrigine blocked the development of mechanical allodynia induced by SNL with suppression of microglial and astrocytic activation. Continuous intrathecal administration of lamotrigine may be a promising therapeutic intervention to prevent neuropathy.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
Colburn RW / 1999 / The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior / Exp Neurol 157 : 289 ~ 304
Datta S / 2004 / Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain / Anesth Analg 98 : 178 ~ 184
Erichsen HK / 2003 / A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain / Eur J Pharmacol 458 : 275
Hilas O / 2007 / Lamotrigine-induced Stevens-Johnson syndrome / Am J Health Syst Pharm 64 : 273 ~ 275
Colburn RW / 1999 / The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior / Exp Neurol 157 : 289 ~ 304
Datta S / 2004 / Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain / Anesth Analg 98 : 178 ~ 184
Erichsen HK / 2003 / A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain / Eur J Pharmacol 458 : 275
Hilas O / 2007 / Lamotrigine-induced Stevens-Johnson syndrome / Am J Health Syst Pharm 64 : 273 ~ 275
이 논문의 저자 정보
최근 본 자료
댓글(0)
0