지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 330 - 335 (6page)
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초록· 키워드
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Purpose: Levodopa is the most effective anti-Parkinsonian agent. It has also been known to exhibit analgesic properties in laboratory and clinical settings. However, studies evaluating its effects on neuropathic pain are limited. The aim of the present study was to examine the anti-allodynic effects of levodopa in neuropathic rats. Materials and Methods: Sprague-Dawley male rats underwent the surgical procedure for L5 and L6 spinal nerves ligation. Sixty neuropathic rats were randomly divided into 6 groups for the oral administration of distilled water and levodopa at 10, 30, 50, 70, and 100 mg/kg, respectively. We co-administered carbidopa with levodopa to prevent peripheral synthesis of dopamine from levodopa, and observed tactile, cold, and heat allodynia pre-administration, and at 15, 30, 60, 90, 120, 150, 180, and 240 min after drug administration. We also measured locomotor function of neuropathic rats using rotarod test to examine whether levodopa caused side effects or not. Results: Distilled water group didn’t show any difference in all allodynia. For the levodopa groups (10-100 mg/kg), tactile and heat withdrawal thresholds were increased, and cold withdrawal frequency was decreased dose-dependently (p<0.01). In addition, levodopa induced biphasic analgesia. Different dosage of levodopa did not impact on the rotarod time (p>0.05). Conclusion: Levodopa reversed tactile, cold and heat allodynia in neuropathic rat without any side effects.
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참고문헌 (36)
참고문헌 신청
Yokoyama C / 1994 / Autoradiographic distribution of [3H]YM-09151-2, a high-affinity and selective antagonist ligand for the dopamine D2 receptor group, in the rat brain and spinal cord / J Comp Neurol 344:121~136
Ansah OB / 2007 / Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat / Exp Neurol 205:536~546
Magnusson JE / 2000 / The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum / Brain Res 855:260~266
Michael-Titus A / 1990 / Stimulation of dopamine D2 receptors induces an analgesia involving an opioidergic but non enkephalinergic link / Eur J Pharmacol 187:201~207
Pertovaara A / 2008 / Dual influence of the striatum on neuropathic hypersensitivity / Pain 137:50~59
Ansah OB / 2007 / Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat / Exp Neurol 205:536~546
Magnusson JE / 2000 / The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum / Brain Res 855:260~266
Michael-Titus A / 1990 / Stimulation of dopamine D2 receptors induces an analgesia involving an opioidergic but non enkephalinergic link / Eur J Pharmacol 187:201~207
Pertovaara A / 2008 / Dual influence of the striatum on neuropathic hypersensitivity / Pain 137:50~59
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