지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,331 - 1,335 (5page)
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초록· 키워드
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Purpose: Klinefelter syndrome (KS) is related to testicular insufficiency, which causes low testosterone levels in serum. Generally, sex hormone levels and bone mineral density (BMD) are lower in patients with KS than normal. We investigated the effects of testosterone replacement on serum testosterone levels and BMD in KS patients. Materials and Methods: From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido®, 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward’s triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. Results: Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p<0.001), and total testosterone rose to normal levels after replacement in all patients. The mean BMD of the lumbar spine increased significantly (0.91 vs. 0.97 g/cm2, p<0.001). Similar increases of BMD were also observed at the femoral neck, but this increase was not significant. Conclusion: These findings suggest that testosterone replacement therapy may be effective in treating BMD deficiency in men with testosterone deficiency, especially those with Klinefelter syndrome.
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참고문헌 (17)
참고문헌 신청
Aminorroaya A / 2005 / Adequacy of androgen replacement influences bone density response to testosterone in androgen-deficient men / Eur J Endocrinol 52 : 881 ~ 886
Choi HR / 1995 / Site-specific effect of testosterone on bone mineral density in male hypogonadism / J Korean Med Sci 10 : 431 ~ 435
De Rosa M / 2001 / Bone mineral density and bone markers in hypogonadotropic and hypergonadotropic hypogonadal men after prolonged testosterone treatment / J Endocrinol Inves
Horowitz M / 1992 / Osteoporosis and Klinefelter’s syndrome / Clin Endocrinol 36 : 113 ~ 118
Isidori AM / 2005 / Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis / Clin Endocrinol 63 : 280 ~ 293
Choi HR / 1995 / Site-specific effect of testosterone on bone mineral density in male hypogonadism / J Korean Med Sci 10 : 431 ~ 435
De Rosa M / 2001 / Bone mineral density and bone markers in hypogonadotropic and hypergonadotropic hypogonadal men after prolonged testosterone treatment / J Endocrinol Inves
Horowitz M / 1992 / Osteoporosis and Klinefelter’s syndrome / Clin Endocrinol 36 : 113 ~ 118
Isidori AM / 2005 / Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis / Clin Endocrinol 63 : 280 ~ 293
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