지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 241 - 247 (7page)
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초록· 키워드
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Autophagy is a specialized cellular pathway involved in maintaining homeostasis by degrading long-lived cellular proteins and organelles. Recent studies have demonstrated that autophagy is utilized by immune systems to protect host cells from invading pathogens and regulate uncontrolled immune responses. During pathogen recognition, induction of autophagy by pattern recognition receptors leads to the promotion or inhibition of consequent signaling pathways. Furthermore, autophagy plays a role in the delivery of pathogen signatures in order to promote the recognition thereof by pattern recognition receptors. In addition to innate recognition,autophagy has been shown to facilitate MHC class II presentation of intracellular antigens to activate CD4 T cells. In this review, we describe the roles of autophagy in innate recognition of pathogens and adaptive immunity, such as antigen presentation, as well as the clinical relevance of autophagy in the treatment of human diseases.
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참고문헌 (28)
참고문헌 신청
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4 : 499 ~ 511
Brazil MI / 1997 / Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules
Chiang HL / 1989 / A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins / Science 246 : 382 ~ 385
Cuervo AM / 1996 / A receptor for the selective uptake and degradation of proteins by lysosomes / Science 273 : 501 ~ 503
Cuervo AM / 2000 / Unique properties of lamp2a compared to other lamp2 isoforms / J Cell Sci 113 (Pt 24) : 4441 ~ 4450
Brazil MI / 1997 / Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules
Chiang HL / 1989 / A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins / Science 246 : 382 ~ 385
Cuervo AM / 1996 / A receptor for the selective uptake and degradation of proteins by lysosomes / Science 273 : 501 ~ 503
Cuervo AM / 2000 / Unique properties of lamp2a compared to other lamp2 isoforms / J Cell Sci 113 (Pt 24) : 4441 ~ 4450
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