지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 842 - 848 (7page)
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Purpose: Pulmonary Kv channels are thought to play a crucial role in the regulation of cell proliferation and apoptosis. Previous studies have shown that fluoxetine upregulated the expression of Kv1.5 and prevented pulmonary arterial hypertension in monocrotaline-induced or hypoxia-induced rats and mice. The current study was designed to test how fluoxetine regulates Kv1.5 channels, subsequently promoting apoptosis in human PASMCs cultured in vitro. Materials and Methods: Human PASMCs were incubated with low-serum DMEM, ET-1, and fluoxetine with and without ET-1 separately for 72 h. Then the proliferation, apoptosis, and expression of TRPC1 and Kv1.5 were detected. Results: In the ET-1 induced group, the upregulation of TRPC1 and down regulation of Kv1.5 enhanced proliferation and anti-apoptosis,which was reversed when treated with fluoxetine. The decreased expression of TRPC1 increased the expression of Kv1.5, subsequently inhibiting proliferation while promoting apoptosis. Conclusion: The results from the present study suggested that fluoxetine protects against big endothelin-1 induced anti-apoptosis and rescues Kv1.5 channels in human pulmonary arterial smooth muscle cells, potentially by decreasing intracellular concentrations of Ca2+.
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참고문헌 (20)
참고문헌 신청
Bonnet S / 2006 / An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn ho
Bonnet S / 2007 / The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted / Proc Natl Acad Sci U S A 104 : 11418 ~ 11423
Burg ED / 2008 / Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications / Br J Pharmacol 1
Fantozzi I / 2006 / Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells / Am J Physio
Farber HW / 2004 / Pulmonary arterial hypertension / N Engl J Med 351 : 1655 ~ 1665
Bonnet S / 2007 / The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted / Proc Natl Acad Sci U S A 104 : 11418 ~ 11423
Burg ED / 2008 / Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications / Br J Pharmacol 1
Fantozzi I / 2006 / Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells / Am J Physio
Farber HW / 2004 / Pulmonary arterial hypertension / N Engl J Med 351 : 1655 ~ 1665
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