지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 839 - 852 (14page)
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초록· 키워드
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Presently, allergy diagnosis and therapy procedures are undergoing a transition phase in which allergen extracts are being step-by-step replaced by molecule-based products. The new developments will allow clinicians to obtain detailed informationon sensitization patterns, more accurate interpretation of allergic symptoms,and thus improved patients’ management. In this respect, recombinant technology has been applied to develop this new generation of molecule-based allergyproducts. The use of recombinant allergens allows full validation of identity, quantity, homogeneity, structure, aggregation, solubility, stability, IgE-binding and the biologic potency of the products. In contrast, such parameters are extremely difficult to assay and standardize for extract-based products. In addition to the possibilityof bulk production of wild type molecules for diagnostic purposes, recombinanttechnology opened the possibility of developing safer and more efficacious products for allergy therapy. A number of molecule-based hypoallergenic preparationshave already been successfully evaluated in clinical trials, bringing forward the next generation of allergy vaccines. In this contribution, we review the latest developments in allergen characterization, molecule-based allergy diagnosis, and the application of recombinant allergens in therapeutic setups. A comprehensive overview of clinical trials using recombinant allergens as well as synthetic peptidesis presented.
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참고문헌 (26)
참고문헌 신청
Akdis M / 2007 / Mechanisms of allergen-specific immunotherapy / J Allergy Clin Immunol 119 : 780 ~ 791
Akkerdaas JH / 2003 / How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents? / Int Arch Allergy Immunol 132 : 132 ~ 140
Canonica GW / 2013 / A WAO-ARIA- GA²LEN consensus document on molecular-based allergy diagnostics / World Allergy Organ J 6 : 17 ~
Curin M / 2011 / Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens / Int Arch Allergy Im
EDQM / / EDQM Annual Report 2011
Akkerdaas JH / 2003 / How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents? / Int Arch Allergy Immunol 132 : 132 ~ 140
Canonica GW / 2013 / A WAO-ARIA- GA²LEN consensus document on molecular-based allergy diagnostics / World Allergy Organ J 6 : 17 ~
Curin M / 2011 / Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens / Int Arch Allergy Im
EDQM / / EDQM Annual Report 2011
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