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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 311 - 321 (11page)
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Purpose: The sarco/endoplasmic reticulum Ca²+-ATPase (SERCA), encoded by ATP2A2, is an essential component for G-protein coupled receptor (GPCR)-dependent Ca²+ signaling. However, whether the changes in Ca²+ signaling and Ca²+ signaling proteins in parotid acinar cells are affected by a partial loss of SERCA2 are not known. Materials and Methods: In SERCA2+/- mouse parotid gland acinar cells, Ca²+ signaling, expression levels of Ca²+ signaling proteins, and amylase secretion were investigated. Results: SERCA2+/- mice showed decreased SERCA2 expression and an upregulation of the plasma membrane Ca²+ ATPase. A partial loss of SERCA2 changed the expression level of 1, 4, 5-tris-inositolphosphate receptors (IP3Rs), but the localization and activities of IP3Rs were not altered. In SERCA2+/- mice, muscarinic stimulation resulted in greater amylase release, and the expression of synaptotagmin was increased compared to wild type mice. Conclusion: These results suggest that a partial loss of SERCA2 affects the expression and activity of Ca²+ signaling proteins in the parotid gland acini, however, overall Ca²+ signaling is unchanged.
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참고문헌 (24)
참고문헌 신청
Anwar A / 2005 / PKC- independent signal transduction pathways increase SERCA2 expression in adult rat cardiomyocytes / J Mol Cell Cardiol 39 : 911 ~ 919
Bernfeld P / 1951 / Enzymes of starch degradation and synthesis / Adv Enzymol Relat Subj Biochem 12 : 379 ~ 428
Berridge MJ / 2003 / Calcium signalling: dynamics, homeostasis and remodelling / Nat Rev Mol Cell Biol 4 : 517 ~ 529
Bolotina VM / 2004 / Store-operated channels: diversity and activation mechanisms / Sci STKE 243 : 1 ~ 4
Chapman ER / 2002 / Synaptotagmin: A Ca2+ sensor that triggers exocytosis? / Nat Rev Mal Cell Biol 3 : 498 ~ 508
Bernfeld P / 1951 / Enzymes of starch degradation and synthesis / Adv Enzymol Relat Subj Biochem 12 : 379 ~ 428
Berridge MJ / 2003 / Calcium signalling: dynamics, homeostasis and remodelling / Nat Rev Mol Cell Biol 4 : 517 ~ 529
Bolotina VM / 2004 / Store-operated channels: diversity and activation mechanisms / Sci STKE 243 : 1 ~ 4
Chapman ER / 2002 / Synaptotagmin: A Ca2+ sensor that triggers exocytosis? / Nat Rev Mal Cell Biol 3 : 498 ~ 508
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