지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 304 - 309 (6page)
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초록· 키워드
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To date, the use of red blood cells (RBCs) produced from stem cells in vitro has not proved practical for routine transfusion. However, the perpetual and widespreadshortage of blood products, problems related to transfusion-transmitted infections,and new emerging pathogens elicit an increasing demand for artificial blood. Worldwide efforts to achieve the goal of RBC production through stem cell research have received vast attention; however, problems with large-scale productionand cost effectiveness have yet to prove practical usefulness. Some progress has been made, though, as cord blood stem cells and embryonic stem cells have shown an ability to differentiate and proliferate, and induced pluripotent stem cells have been shown to be an unlimited source for RBC production. However, transfusionof stem cell-derived RBCs still presents a number of challenges to overcome. This paper will summarize an up to date account of research and advances in stem cell-derived RBCs, delineate our laboratory protocol in producing RBCs from cord blood, and introduce the technological developments and limitations to current RBC production practices.
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참고문헌 (33)
참고문헌 신청
Kaufman DS / 2001 / Hematopoietic colony-forming cells derived from human embryonic stem cells / Proc Natl Acad Sci U S A 98:10716~10721
Ma F / 2008 / Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis / Proc Natl Acad Sci U S A 105:13087~13092
Mountford JC / 2010 / Red blood cells from pluripotent stem cells for use in transfusion / Regen Med 5:411~423
Lu SJ / 2008 / Biologic properties and enucleation of red blood cells from human embryonic stem cells / Blood 112:4475~4484
Lapillonne H / 2010 / Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine / Haematologica 95:1651~1659
Ma F / 2008 / Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis / Proc Natl Acad Sci U S A 105:13087~13092
Mountford JC / 2010 / Red blood cells from pluripotent stem cells for use in transfusion / Regen Med 5:411~423
Lu SJ / 2008 / Biologic properties and enucleation of red blood cells from human embryonic stem cells / Blood 112:4475~4484
Lapillonne H / 2010 / Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine / Haematologica 95:1651~1659
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