지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 700 - 708 (9page)
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Purpose: We previously reported that insulin resistance, low high-density lipoprotein(HDL) cholesterol, and glycaemic exposure Index are independently associated with peripheral neuropathy in Korean patients with type 2 diabetes mellitus. We followedthe patients who participated in that study in 2006 for another 6 years to determinethe relationship between insulin resistance and neuropathy. Materials and Methods: This study involved 48 of the original 86 Korean patients with type 2 diabetesmellitus who were referred to the Neurology clinic for the assessment of diabeticneuropathy from January 2006 to December 2006. These 48 patients received management for glycaemic control and prevention of diabetic complications in the outpatient clinic up to 2012. We reviewed blood test results and the nerve conduction study findings of these patients, taken over a 6-year period. Results: Low HDL cholesteroland high triglycerides significantly influenced the development of diabetic neuropathy. Kitt value (1/insulin resistance) in the previous study affected the occurrenceof neuropathy, despite adequate glycaemic control with HbA1c <7%. Insulin resistance affected the development of diabetic neuropathy after 6 years: insulin resistancein 2006 showed a positive correlation with a change in sural sensory nerve action potential in 2012. Conclusion: Diabetic neuropathy can be affected by previousinsulin resistance despite regular glycaemic control. Dyslipidaemia should be controlled in patients who show high insulin resistance because HDL cholesterol and triglycerides are strongly correlated with later development of diabetic neuropathy.
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참고문헌 (31)
참고문헌 신청
Woo V / 2008 / Targets and tactics: the relative importance of HbA, fasting and postprandial plasma glucose levels to glycaemic control in type 2 diabetes / Int J Clin Pract 62:1935~1942
Nathan DM / 2009 / Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes / Diabetes Care 32:193~203
Inzucchi SE / 2012 / Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) / Diabetologia 55:1577~1596
American Diabetes Association / 2012 / Standards of medical care in diabetes--2012 / Diabetes Care 35(Suppl 1):S11~S63
El-Salem K / 2009 / Elevated glycosylated hemoglobin is associated with subclinical neuropathy in neurologically asymptomatic diabetic patients: a prospective study / J Clin Neurophysiol 26:50~53
Nathan DM / 2009 / Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes / Diabetes Care 32:193~203
Inzucchi SE / 2012 / Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) / Diabetologia 55:1577~1596
American Diabetes Association / 2012 / Standards of medical care in diabetes--2012 / Diabetes Care 35(Suppl 1):S11~S63
El-Salem K / 2009 / Elevated glycosylated hemoglobin is associated with subclinical neuropathy in neurologically asymptomatic diabetic patients: a prospective study / J Clin Neurophysiol 26:50~53
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