지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,473 - 1,483 (11page)
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초록· 키워드
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Purpose: Cefaclor is widely prescribed for various infectious diseases. As its consumptionincreases, the number of hypersensitivity reactions to cefaclor has increased. This study aimed to evaluate the immunologic findings of immediate hypersensitivityto cefaclor. Materials and Methods: We enrolled 47 patients with immediate hypersensitivity to cefaclor from Ajou University Hospital and Asan Medical Center. Serum specific IgE, IgG1, and IgG4 antibodies to cefaclor-human serum albumin (HSA) conjugate were measured by enzyme-linked immunosorbentassay (ELISA). Results: The most common phenotype was anaphylaxis (Group I, 78.7%), followed by urticaria (Group II, 21.3%). The detection of specificIgE, IgG1, and IgG4 to cefaclor-HSA conjugate by ELISA tended to be higher in Group I (40.5%, 41.7%, 21.6%) than in Group II (20.0%, 20.0%, 0%) with no statistical significance. Significant associations were found between specific IgE and IgG1 or IgG4 (p<0.001, p=0.019). ELISA inhibition tests showed significant inhibitions by both free cefaclor and cefaclor-HSA conjugate. For basophil activationtests in patients having no specific IgE antibody, the CD63 expression level on basophils increased with incubations of free cefaclor. Conclusion: The most commonmanifestation of immediate hypersensitivity to cefaclor was anaphylaxis, most of which was mediated by IgE; however, a non-IgE mediated direct basophil activation mechanism was suggested in a subset of anaphylaxis patients.
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참고문헌 (27)
참고문헌 신청
Anne S / 1995 / Risk of administering cephalosporin antibiotics to patients with histories of penicillin allergy / Ann Allergy Asthma Immunol 74 : 167 ~ 170
Atanaskovi?-Markovi? M / 2005 / Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children / Pediatr Allergy Immunol 16 : 341 ~ 347
Beghetti M / 1998 / Hypersensitivity myocarditis caused by an allergic reaction to cefaclor / J Pediatr 132 : 172 ~ 173
Ben-Shoshan M / 2011 / Anaphylaxis: past, present and future / Allergy 66 : 1 ~ 14
Blanca M / 2009 / Update on the evaluation of hypersensitivity reactions to betalactams / Allergy 64 : 183 ~ 193
Atanaskovi?-Markovi? M / 2005 / Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children / Pediatr Allergy Immunol 16 : 341 ~ 347
Beghetti M / 1998 / Hypersensitivity myocarditis caused by an allergic reaction to cefaclor / J Pediatr 132 : 172 ~ 173
Ben-Shoshan M / 2011 / Anaphylaxis: past, present and future / Allergy 66 : 1 ~ 14
Blanca M / 2009 / Update on the evaluation of hypersensitivity reactions to betalactams / Allergy 64 : 183 ~ 193
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