지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,568 - 1,575 (8page)
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Purpose: The modified Glasgow Prognostic Score (mGPS) consisting of serum C-reactive protein and albumin levels, shows significant prognostic value in severaltypes of tumors. We evaluated the prognostic significance of mGPS in 285 patientswith diffuse large B cell lymphoma (DLBCL), retrospectively. Materials and Methods: According to mGPS classification, 204 patients (71.5%) had an mGPS of 0, 57 (20%) had an mGPS of 1, and 24 (8.5%) had an mGPS of 2. Results:Our study found that high mGPS were associated with poor prognostic factorsincluding older age, extranodal involvement, advanced disease stage, unfavorableInternational Prognostic Index scores, and the presence of B symptoms. The complete response (CR) rate after 3 cycles of R-CHOP chemotherapy was higher in patients with mGPS of 0 (53.8%) compared to those with mGPS of 1 (33.3%) or 2 (25.0%) (p=0.001). Patients with mGPS of 0 had significantly better overall survival (OS) than those with mGPS=1 and those with mGPS=2 (p=0.036). Multivariateanalyses revealed that the GPS score was a prognostic factor for the CR rate of 3 cycle R-CHOP therapy (p=0.044) as well as OS (p=0.037). Conclusion: mGPS can be considered a potential prognostic factor that may predict early responsesto R-CHOP therapy in DLBCL patients.
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참고문헌 (24)
참고문헌 신청
/ 1993 / A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project / N Engl J Med 329 : 987 ~ 994
Cheson BD / 1999 / Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group / J Clin Onco
Coiffier B / 2002 / CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma / N Engl J Med 346 : 235 ~ 242
Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
Dunn GP / 2005 / A critical function for type I interferons in cancer immunoediting / Nat Immunol 6 : 722 ~ 729
Cheson BD / 1999 / Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group / J Clin Onco
Coiffier B / 2002 / CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma / N Engl J Med 346 : 235 ~ 242
Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
Dunn GP / 2005 / A critical function for type I interferons in cancer immunoediting / Nat Immunol 6 : 722 ~ 729
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